PMID- 16859081
OWN - NLM
STAT- MEDLINE
DCOM- 20061218
LR  - 20141006
IS  - 0300-9033 (Print)
IS  - 0300-9033 (Linking)
VI  - 36
IP  - 2
DP  - 2006 Jun
TI  - [Clinical-phmetric variants in gastroesophageal reflux disease].
PG  - 81-5
AB  - BACKGROUND: Ambulatory pH monitoring, that defines acid reflux episodes as a fall 
      in pH below 4, fail to diagnose weakly acidic reflux, which sometimes is related 
      to the occurrence of symptoms. AIM: To establish the incidence of 
      clinical-phmetric variables that allow to confirm or discard the presence of 
      gastroesophageal reflux and its symptomatic correlation. PATIENTS AND METHODS: 
      [corrected] During a period of 12 months, 100 patients (58 males and 42 females) 
      were consecutively included for 24 hour esophageal ambulatory phmetry. The 
      variables considered were: number of symptomatic episodes during the study, 
      number of episodes with positive symptomatic correlation for pH drop greater than 
      4, number of episodes with positive symptomatic correlation for pH drop lower 
      than 4 and Demeester score. For operative reasons we divided the patients in six 
      groups: without evidence of acidic reflux (WAR), hypoalgesic pathologic acid 
      reflux (HPAR), normoalgesic pathologic acid reflux (NPAR), hyperalgesic 
      pathologic acid reflux (HyPAR), allodinic pathologic reflux (APR), hyperalgesic 
      physiologic acid reflux (HyPhAR) and allodynic physiologic acid reflux (APhAR). 
      RESULTS: 18% presented WAR, 7% HPAR, 36% NPAR, 14% HyPAR, 18% HyPhAR and 7% 
      APhAR. The patients with pathologic acid reflux presented more episodes with 
      positive symptomatic correlation than patients without pathologic reflux (P = 
      0.0008). Based on acid reflux intensity and presence or absence of symptomatic 
      correlation, six groups of patients with gastroesophageal reflux disease were 
      differentiated, and probably they should be evaluated and treated in a different 
      way.
FAU - Soifer, Luis O
AU  - Soifer LO
AD  - Servicio de Gastroenterologia, Seccion Motilidady Estudios Funcionales del CEMIC 
      y UNIMOT, Buenos Aires, Argentina. luisosoifer@fibertel.com.ar
FAU - Dima, Guillermo
AU  - Dima G
FAU - Peralta, Daniel
AU  - Peralta D
FAU - Besasso, Horacio
AU  - Besasso H
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Variantes clinico-phmetricas en la enfermedad por reflujo gastroesofagico.
PL  - Argentina
TA  - Acta Gastroenterol Latinoam
JT  - Acta gastroenterologica Latinoamericana
JID - 0261505
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Case-Control Studies
MH  - Chi-Square Distribution
MH  - *Esophageal pH Monitoring
MH  - Female
MH  - *Gastric Acidity Determination
MH  - Gastroesophageal Reflux/diagnosis/*physiopathology
MH  - Humans
MH  - Male
MH  - Manometry/methods
MH  - Middle Aged
MH  - Prospective Studies
EDAT- 2006/07/25 09:00
MHDA- 2006/12/19 09:00
CRDT- 2006/07/25 09:00
PHST- 2006/07/25 09:00 [pubmed]
PHST- 2006/12/19 09:00 [medline]
PHST- 2006/07/25 09:00 [entrez]
PST - ppublish
SO  - Acta Gastroenterol Latinoam. 2006 Jun;36(2):81-5.