PMID- 16859675
OWN - NLM
STAT- MEDLINE
DCOM- 20070112
LR  - 20131121
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 544
IP  - 1-3
DP  - 2006 Aug 21
TI  - Protective effects of minocycline on 3,4-methylenedioxymethamphetamine-induced 
      neurotoxicity in serotonergic and dopaminergic neurons of mouse brain.
PG  - 1-9
AB  - The repeated administration of 3,4-methylenedioxymethamphetamine (MDMA) produces 
      neurotoxicity in the 5-hydroxytryptamine (5-HT) and dopamine systems of the 
      brain. In this study, we investigated the effects of minocycline, a 
      second-generation tetracycline derivative, on MDMA-induced neurotoxicity in the 
      5-HT and dopaminergic systems of the mouse brain. The repeated administration of 
      MDMA (10 mg/kg x 3, 3-h intervals, s.c.) significantly decreased the contents of 
      5-HT and its major metabolite 5-hydroxyindole acetic acid (5-HIAA) in the frontal 
      cortex and hippocampus, and the density of the 5-HT transporter (5-HTT) in the 
      frontal cortex, hippocampus and striatum. The repeated administration of MDMA (10 
      mg/kg x 3, 3-h intervals, s.c.) significantly decreased the contents of the 
      dopamine and the density of the dopamine transporter (DAT) in the striatum, but 
      not the frontal cortex. Furthermore, pretreatment and the subsequent 
      administration of minocycline (40 mg/kg, i.p.) significantly attenuated the 
      reduction of 5-HT and dopamine as well as the density of 5-HTT and DAT in the 
      mouse brain by the repeated administration of MDMA. Moreover, pretreatment and 
      the subsequent administration of minocycline (40 mg/kg) significantly attenuated 
      the increase of activated microglia in the hippocampus and striatum after the 
      repeated administration of MDMA. Our findings suggest that minocycline protects 
      the neurotoxicity of the 5-HT and dopamine systems in the mouse brain after the 
      administration of MDMA.
FAU - Zhang, Lin
AU  - Zhang L
AD  - Division of Clinical Neuroscience, Chiba University Center for Forensic Mental 
      Health, 1-8-1 Inohana, Chiba 260-8670, Japan.
FAU - Shirayama, Yukihiko
AU  - Shirayama Y
FAU - Shimizu, Eiji
AU  - Shimizu E
FAU - Iyo, Masaomi
AU  - Iyo M
FAU - Hashimoto, Kenji
AU  - Hashimoto K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060603
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Anti-Bacterial Agents)
RN  - 333DO1RDJY (Serotonin)
RN  - 54-16-0 (Hydroxyindoleacetic Acid)
RN  - FYY3R43WGO (Minocycline)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/pharmacology
MH  - Brain/*drug effects/metabolism
MH  - Chromatography, High Pressure Liquid
MH  - Dopamine/*metabolism
MH  - Dose-Response Relationship, Drug
MH  - Hydroxyindoleacetic Acid/pharmacology
MH  - Male
MH  - Mice
MH  - Microglia/drug effects
MH  - Minocycline/*pharmacology
MH  - N-Methyl-3,4-methylenedioxyamphetamine/pharmacology/*toxicity
MH  - Neurons/*metabolism
MH  - Serotonin/*metabolism/pharmacology
EDAT- 2006/07/25 09:00
MHDA- 2007/01/16 09:00
CRDT- 2006/07/25 09:00
PHST- 2006/03/31 00:00 [received]
PHST- 2006/05/15 00:00 [revised]
PHST- 2006/05/16 00:00 [accepted]
PHST- 2006/07/25 09:00 [pubmed]
PHST- 2007/01/16 09:00 [medline]
PHST- 2006/07/25 09:00 [entrez]
AID - S0014-2999(06)00541-3 [pii]
AID - 10.1016/j.ejphar.2006.05.047 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2006 Aug 21;544(1-3):1-9. doi: 10.1016/j.ejphar.2006.05.047. 
      Epub 2006 Jun 3.