PMID- 16860955 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20061128 LR - 20060918 IS - 0379-0738 (Print) IS - 0379-0738 (Linking) VI - 162 IP - 1-3 DP - 2006 Oct 16 TI - Impurity profiling of ecstasy tablets seized in Hong Kong by gas chromatography-mass spectrometry. PG - 87-94 AB - In Hong Kong, ecstasy tablets are more commonly known as "Fing Tau Yuen", literally meaning "Shake Head Pills". The tablets contain mainly amphetamine-type stimulants (ATS) including 3,4-methylenedioxymethamphetamine (MDMA), 3,4-methylenedioxyamphetamine (MDA), methamphetamine (MA) and/or ketamine. Adulterant such as caffeine was also detected in the tablets. This paper reports a study on the impurity profiles of ecstasy tablets from 89 seizures in Hong Kong from 2002 to early 2004. Tablet samples were extracted by diethyl ether under alkaline condition and then analyzed by gas GC-MS. The chromatograms obtained were compared. A total of 19 identified impurities were selected as markers for impurity profiling. They are different precursors, intermediates and by-products. The data matrices were examined by hierarchical cluster analysis (HCA), and then the ecstasy tablets were classified into different groups. Cluster analysis of ecstasy tablets is shown to be capable of providing intelligence on clandestine laboratory networks. FAU - Cheng, Jack Yuk Ki AU - Cheng JY AD - Forensic Science Division, Hong Kong Government Laboratory, Ho Man Tin Government Offices, 88 Chung Hau Street, Hong Kong, SAR, China. jcheng@govtlab.gov.hk FAU - Chan, Man Fai AU - Chan MF FAU - Chan, Tai Wai AU - Chan TW FAU - Hung, Mei Yuen AU - Hung MY LA - eng PT - Journal Article DEP - 20060724 PL - Ireland TA - Forensic Sci Int JT - Forensic science international JID - 7902034 EDAT- 2006/07/25 09:00 MHDA- 2006/07/25 09:01 CRDT- 2006/07/25 09:00 PHST- 2005/11/19 00:00 [received] PHST- 2006/02/22 00:00 [revised] PHST- 2006/02/22 00:00 [accepted] PHST- 2006/07/25 09:00 [pubmed] PHST- 2006/07/25 09:01 [medline] PHST- 2006/07/25 09:00 [entrez] AID - S0379-0738(06)00394-X [pii] AID - 10.1016/j.forsciint.2006.02.055 [doi] PST - ppublish SO - Forensic Sci Int. 2006 Oct 16;162(1-3):87-94. doi: 10.1016/j.forsciint.2006.02.055. Epub 2006 Jul 24.