PMID- 16862745
OWN - NLM
STAT- MEDLINE
DCOM- 20060818
LR  - 20190917
IS  - 0030-154X (Print)
IS  - 0030-154X (Linking)
VI  - 83
IP  - 1
DP  - 2006 May
TI  - Effects of chronic ethanol administration on the expression levels of 
      neurotrophic factors in the rat hippocampus.
PG  - 1-6
AB  - Chronic ethanol consumption has adverse effects on the central nervous system. 
      Hippocampus is one of the target sites of ethanol neurotoxicity. Hippocampal 
      damage is known to result in impairment of learning and memory. This study was 
      aimed to determine whether chronic ethanol consumption could alter the expression 
      levels of brain-derived neurotrophic factor (BDNF) and glial-derived neurotrophic 
      factor (GDNF) mRNAs in the hippocampus. Male Wistar rats were given unrestricted 
      access to a liquid diet containing 5% (v/v) ethanol as the sole fluid source for 
      19 weeks beginning at 10 weeks of age. The expression levels of BDNF and GDNF 
      mRNAs in the hippocampus were analyzed by real-time reverse 
      transcription-polymerase chain reaction (RT-PCR) analysis. The present study 
      revealed that chronic ethanol consumption did not result in significant changes 
      in the expression levels of BDNF and GDNF mRNAs. Our present results showed no 
      significant alteration in the expression of these neurotrophic factors; these 
      results will lead to further studies to examine the possible alterations in the 
      gene expression of various neurotrophins that are related to hippocampal 
      functions including learning and memory.
FAU - Okamoto, Hanayo
AU  - Okamoto H
AD  - Department of Neuropsychiatry, Faculty of Medicine, Kagawa University, Japan.
FAU - Miki, Takanori
AU  - Miki T
FAU - Lee, Kyoung-Youl
AU  - Lee KY
FAU - Yokoyama, Toshifumi
AU  - Yokoyama T
FAU - Kuma, Hiromi
AU  - Kuma H
FAU - Gu, He
AU  - Gu H
FAU - Li, Hong-Peng
AU  - Li HP
FAU - Matsumoto, Yoshiki
AU  - Matsumoto Y
FAU - Yamaoka, Ippei
AU  - Yamaoka I
FAU - Fusumada, Kazutoshi
AU  - Fusumada K
FAU - Imagawa, Tomohiro
AU  - Imagawa T
FAU - Wang, Zhi-Yu
AU  - Wang ZY
FAU - Nakamura, Yu
AU  - Nakamura Y
FAU - Takeuchi, Yoshiki
AU  - Takeuchi Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Okajimas Folia Anat Jpn
JT  - Okajimas folia anatomica Japonica
JID - 0401014
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Central Nervous System Depressants)
RN  - 0 (Glial Cell Line-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Alcohol-Related Disorders/*metabolism/pathology
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Central Nervous System Depressants/*toxicity
MH  - Diet
MH  - Disease Models, Animal
MH  - Ethanol/*toxicity
MH  - Gene Expression/drug effects
MH  - Glial Cell Line-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Hippocampus/*drug effects/metabolism/pathology
MH  - Male
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Reverse Transcriptase Polymerase Chain Reaction
EDAT- 2006/07/26 09:00
MHDA- 2006/08/19 09:00
CRDT- 2006/07/26 09:00
PHST- 2006/07/26 09:00 [pubmed]
PHST- 2006/08/19 09:00 [medline]
PHST- 2006/07/26 09:00 [entrez]
AID - 10.2535/ofaj.83.1 [doi]
PST - ppublish
SO  - Okajimas Folia Anat Jpn. 2006 May;83(1):1-6. doi: 10.2535/ofaj.83.1.