PMID- 16864550
OWN - NLM
STAT- MEDLINE
DCOM- 20060810
LR  - 20191026
IS  - 1091-7691 (Electronic)
IS  - 0895-8378 (Linking)
VI  - 18
IP  - 9
DP  - 2006 Aug
TI  - Nasal responses in asthmatic and nonasthmatic subjects following exposure to 
      diesel exhaust particles.
PG  - 589-94
AB  - Asthma rates have been increasing worldwide, and exposure to diesel exhaust 
      particles (DEP) may be implicated in this increase. DEP may also play a role in 
      the increased morbidity and mortality associated with ambient airborne 
      particulate matter (PM) exposure. Two types of nasal responses have been reported 
      for human subjects nasally instilled with one type of DEP: alterations in 
      cytokines responses, and an increase in immunoglobulin E (IgE) production. Since 
      DEP composition can vary depending on several factors, including fuel composition 
      and engine load, the ability of another DEP particle and ozone-treated DEP to 
      alter nasal IgE and cytokine production was examined. Nonasthmatic and asthmatic 
      subjects were intranasally instilled with 300 microg NIST 1650 DEP per nostril, 
      NIST 1650 DEP previously exposed to ozone (ozDEP; 300 microg/nostril), or 
      vehicle. Subjects underwent nasal lavage before DEP exposure, and 4 and 96 h 
      after exposure. Nasal cell populations and soluble mediators in the nasal lavage 
      fluid were characterized. Total cell number, cell types, cell viability, 
      concentrations of soluble mediators (including interleukin [IL]-8, IL-6, IgE, and 
      granulocyte-macrophage colony-stimulating factor [GM-CSF]) were not altered by 
      either DEP or ozDEP exposure. NO levels were not altered by either particle 
      exposure. These findings suggest that DEP can be relatively noninflammatory and 
      nontoxic, and that the physicochemical characteristics of DEP need to be 
      considered when assessing the health effects of exposure to diesel exhaust.
FAU - Kongerud, Johny
AU  - Kongerud J
AD  - Lungeavdelingen, Rikshospitalet, University of Oslo, Oslo, Norway.
FAU - Madden, Michael C
AU  - Madden MC
FAU - Hazucha, Milan
AU  - Hazucha M
FAU - Peden, David
AU  - Peden D
LA  - eng
PT  - Journal Article
PL  - England
TA  - Inhal Toxicol
JT  - Inhalation toxicology
JID - 8910739
RN  - 0 (Air Pollutants)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-6)
RN  - 0 (Interleukin-8)
RN  - 0 (Vehicle Emissions)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 66H7ZZK23N (Ozone)
RN  - 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor)
SB  - IM
MH  - Administration, Intranasal
MH  - Adolescent
MH  - Adult
MH  - Air Pollutants/*adverse effects
MH  - Asthma/*etiology/metabolism/pathology
MH  - Cell Count
MH  - Cell Survival/drug effects
MH  - Cytokines/metabolism
MH  - Female
MH  - Granulocyte-Macrophage Colony-Stimulating Factor/metabolism
MH  - Humans
MH  - Immunoglobulin E/analysis
MH  - Interleukin-6/metabolism
MH  - Interleukin-8/metabolism
MH  - Male
MH  - Middle Aged
MH  - Nasal Lavage Fluid/chemistry/cytology
MH  - Nasal Mucosa/*drug effects/metabolism/pathology
MH  - Neutrophils/drug effects/metabolism/pathology
MH  - Ozone/administration & dosage
MH  - Vehicle Emissions/*adverse effects
EDAT- 2006/07/26 09:00
MHDA- 2006/08/11 09:00
CRDT- 2006/07/26 09:00
PHST- 2006/07/26 09:00 [pubmed]
PHST- 2006/08/11 09:00 [medline]
PHST- 2006/07/26 09:00 [entrez]
AID - V20134862227X303 [pii]
AID - 10.1080/08958370600743027 [doi]
PST - ppublish
SO  - Inhal Toxicol. 2006 Aug;18(9):589-94. doi: 10.1080/08958370600743027.