PMID- 16864870
OWN - NLM
STAT- MEDLINE
DCOM- 20061019
LR  - 20131121
IS  - 1525-3163 (Electronic)
IS  - 0021-8812 (Linking)
VI  - 84
IP  - 8
DP  - 2006 Aug
TI  - Supplementing drinking water with Solutein did not mitigate acute morbidity 
      effects of porcine reproductive and respiratory syndrome virus in nursery pigs.
PG  - 2101-9
AB  - The objective of this study was to determine whether providing nursery pigs 
      drinking water supplemented with spray-dried animal plasma (Solutein, American 
      Protein Corporation Inc., Ankeny, IA) would reduce the detrimental impact of 
      porcine reproductive and respiratory syndrome virus (PRRSV) infection. Sixty-four 
      pigs were subjected to 1 of 4 treatment combinations (2 x 2 factorial 
      arrangement) of Solutein [0 or 2.5% (wt/wt) in drinking water] and PRRSV (sterile 
      medium or 5 mL of tissue culture infectious dose of high-virulence strain ATCC 
      VR-2385). Pigs were provided the water treatments during a 1-wk period before 
      inoculation as well as during a 2-wk period after inoculation. Growth performance 
      was determined throughout the study, and several indicators of the immunological 
      response to PRRSV and disease pathology were assessed in blood and tissue samples 
      collected from pigs killed 7 or 14 d after inoculation. Before inoculation, pigs 
      provided water supplemented with Solutein tended to eat less (P = 0.08) but 
      tended to gain more BW (P = 0.13) than pigs provided tap water. Thus, Solutein 
      markedly improved G:F (P < 0.01), after accounting for the DM provided by 
      Solutein. Inoculation with PRRSV reduced ADG and ADFI (P < 0.01) irrespective of 
      water treatment; however, the beneficial effects of Solutein on G:F persisted. 
      Infection with PRRSV also reduced (P < 0.009) villus height and crypt depth in 
      cranial, medial, and caudal segments of the small intestine and increased (P < 
      0.05) lung and spleen weight, the number of leukocytes in lung lavage fluid, and 
      serum concentrations of interferon-gamma and IL-1beta regardless of water 
      treatment. Collectively, these results indicate that supplementing water with 
      spray-dried animal plasma improved feed efficiency but did not afford nursery 
      pigs protection from the effects of PRRSV on growth and certain hematological 
      traits.
FAU - Escobar, J
AU  - Escobar J
AD  - Department of Animal Sciences, University of Illinois, Urbana 61801, USA.
FAU - Toepfer-Berg, T L
AU  - Toepfer-Berg TL
FAU - Chen, J
AU  - Chen J
FAU - Van Alstine, W G
AU  - Van Alstine WG
FAU - Campbell, J M
AU  - Campbell JM
FAU - Johnson, R W
AU  - Johnson RW
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - J Anim Sci
JT  - Journal of animal science
JID - 8003002
RN  - 0 (Interleukin-1)
RN  - 059QF0KO0R (Water)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - Female
MH  - Interferon-gamma/blood
MH  - Interleukin-1/blood
MH  - Intestine, Small/pathology
MH  - Leukocyte Count
MH  - Liver/pathology
MH  - Lung/pathology
MH  - Male
MH  - Organ Size
MH  - Plasma/chemistry/*metabolism
MH  - Porcine Reproductive and Respiratory Syndrome/*pathology
MH  - Spleen/pathology
MH  - Swine
MH  - Water/*chemistry
EDAT- 2006/07/26 09:00
MHDA- 2006/10/20 09:00
CRDT- 2006/07/26 09:00
PHST- 2006/07/26 09:00 [pubmed]
PHST- 2006/10/20 09:00 [medline]
PHST- 2006/07/26 09:00 [entrez]
AID - 84/8/2101 [pii]
AID - 10.2527/jas.2005-616 [doi]
PST - ppublish
SO  - J Anim Sci. 2006 Aug;84(8):2101-9. doi: 10.2527/jas.2005-616.