PMID- 16865785
OWN - NLM
STAT- MEDLINE
DCOM- 20060905
LR  - 20221207
IS  - 1007-9327 (Print)
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Linking)
VI  - 12
IP  - 27
DP  - 2006 Jul 21
TI  - A functional variant in the CD209 promoter is associated with DQ2-negative celiac 
      disease in the Spanish population.
PG  - 4397-400
AB  - AIM: To address the role of CD209 in celiac disease (CD) patients. Non-human 
      leukocyte antigen (HLA) genetic factors in CD predisposition are poorly 
      understood, and environmental factors like infectious pathogens may play a role. 
      CD209 is a dendritic and macrophage surface molecule involved in pathogen 
      recognition and immune activation. Recently, a functional variant in the promoter 
      of the CD209 gene (-336A/G) has been shown to affect the transcriptional CD209 
      activity in vitro and it has been associated with a higher susceptibility to/or 
      severity of infection. METHODS: The study population was composed of two 
      case-control cohorts of 103 and 386 CD patients and 312 y 419 healthy controls as 
      well as a panel of 257 celiac families. Genotyping for the -336A/G CD209 promoter 
      polymorphism was performed using a TaqMan 5' allelic discrimination assay. HLA-DQ 
      was determined by hybridization with allele specific probes. RESULTS: Initially, 
      the case-control and familial studies did not find any association of the -336 
      A/G CD209 genetic variant with CD susceptibility. However, the stratification by 
      HLA-DQ2 did reveal a significant association of CD209 promoter polymorphism in 
      the HLA-DQ2 (-) group (carrier A vs GG in DQ2 (-) vs DQ2 (+) patients (P = 0.026, 
      OR = 3.71). CONCLUSION: The -336G CD209 allele seems to be involved in CD 
      susceptibility in HLA-DQ2 (-) patients. Our results might suggest a possible role 
      of pathogens in the onset of a minor group of CD patients.
FAU - Nunez, C
AU  - Nunez C
AD  - Servicio de Inmunologia Clinica, Hospital Clinico San Carlos, Madrid 28040, 
      Spain.
FAU - Rueda, B
AU  - Rueda B
FAU - Martinez, A
AU  - Martinez A
FAU - Maluenda, C
AU  - Maluenda C
FAU - Polanco, I
AU  - Polanco I
FAU - Lopez-Nevot, M-A
AU  - Lopez-Nevot MA
FAU - Ortega, E
AU  - Ortega E
FAU - Sierra, E
AU  - Sierra E
FAU - Gomez de la Concha, E
AU  - Gomez de la Concha E
FAU - Urcelay, E
AU  - Urcelay E
FAU - Martin, J
AU  - Martin J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (DC-specific ICAM-3 grabbing nonintegrin)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ2 antigen)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Receptors, Cell Surface)
SB  - IM
MH  - Alleles
MH  - Case-Control Studies
MH  - Celiac Disease/epidemiology/ethnology/*genetics/physiopathology
MH  - Cell Adhesion Molecules/*genetics/physiology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - HLA-DQ Antigens/*genetics/physiology
MH  - Humans
MH  - Lectins, C-Type/*genetics/physiology
MH  - Male
MH  - Polymorphism, Genetic
MH  - Promoter Regions, Genetic/*genetics/physiology
MH  - Receptors, Cell Surface/*genetics/physiology
MH  - Severity of Illness Index
MH  - Spain/epidemiology/ethnology
MH  - White People/genetics
PMC - PMC4087754
EDAT- 2006/07/26 09:00
MHDA- 2006/09/06 09:00
PMCR- 2006/07/21
CRDT- 2006/07/26 09:00
PHST- 2006/07/26 09:00 [pubmed]
PHST- 2006/09/06 09:00 [medline]
PHST- 2006/07/26 09:00 [entrez]
PHST- 2006/07/21 00:00 [pmc-release]
AID - 10.3748/wjg.v12.i27.4397 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2006 Jul 21;12(27):4397-400. doi: 
      10.3748/wjg.v12.i27.4397.