PMID- 16865869
OWN - NLM
STAT- MEDLINE
DCOM- 20061114
LR  - 20220408
IS  - 1545-9616 (Print)
IS  - 1545-9616 (Linking)
VI  - 5
IP  - 7
DP  - 2006 Jul-Aug
TI  - Similar effectiveness of methyl aminolevulinate and 5-aminolevulinate in topical 
      photodynamic therapy for nodular basal cell carcinoma.
PG  - 642-5
AB  - BACKGROUND: Photodynamic therapy (PDT) for basal cell carcinoma (BCC) is a 
      treatment modality that is increasingly used in dermato-oncology. Currently, 2 
      topical photosensitizers, 5-aminolevulinate (ALA) and methyl aminolevulinate 
      (MAL) are widely used, but their efficacy in BCC has not yet been compared in a 
      clinical setting. OBJECTIVE: To evaluate the effect, degree of pain, and costs of 
      ALA-PDT versus MAL-PDT in nodular BCC (nBCC). METHODS: Patients suffering from 
      BCC were randomly assigned to either ALA-PDT (n=22) or MAL-PDT (n=21) in a pilot 
      study. In each group, half of the tumors were debulked prior to PDT. Eight weeks 
      after treatment, the therapeutic outcome was checked histologically. Pain scores 
      were assessed using a visual analogue scale. RESULTS: Residual tumor tissue was 
      detected in 6 BCCs of each study group. No significant difference between ALA-PDT 
      and MAL-PDT was found with regard to therapeutic efficacy and pain scores. Of 
      note, however, the costs of MAL-PDT were 6-fold higher than those of ALA-PDT. 
      CONCLUSIONS: In this study we did not observe any differences in short-term 
      efficacy between ALA-PDT and MAL-PDT. Therefore, both ALA and MAL can be equally 
      recommended as topical photosensitizers in PDT.
FAU - Kuijpers, Danielle I
AU  - Kuijpers DI
AD  - Department of Dermatology, University Hospital Maastricht, Maastricht, The 
      Netherlands. dku@sder.azm.nl
FAU - Thissen, Monique R
AU  - Thissen MR
FAU - Thissen, Carleine A
AU  - Thissen CA
FAU - Neumann, Martino H
AU  - Neumann MH
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - J Drugs Dermatol
JT  - Journal of drugs in dermatology : JDD
JID - 101160020
RN  - 0 (Photosensitizing Agents)
RN  - 88755TAZ87 (Aminolevulinic Acid)
SB  - IM
MH  - Administration, Topical
MH  - Aminolevulinic Acid/administration & dosage/*analogs & derivatives/*therapeutic 
      use
MH  - Carcinoma, Basal Cell/*drug therapy
MH  - Humans
MH  - Pain Measurement
MH  - *Photochemotherapy
MH  - Photosensitizing Agents/therapeutic use
MH  - Pilot Projects
MH  - Skin Neoplasms/*drug therapy
MH  - Treatment Outcome
EDAT- 2006/07/27 09:00
MHDA- 2006/11/15 09:00
CRDT- 2006/07/27 09:00
PHST- 2006/07/27 09:00 [pubmed]
PHST- 2006/11/15 09:00 [medline]
PHST- 2006/07/27 09:00 [entrez]
PST - ppublish
SO  - J Drugs Dermatol. 2006 Jul-Aug;5(7):642-5.