PMID- 1686679
OWN - NLM
STAT- MEDLINE
DCOM- 19920407
LR  - 20190824
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 38
IP  - 3
DP  - 1991 Sep
TI  - HLA-DP and susceptibility to insulin-dependent diabetes mellitus in Japanese.
PG  - 107-10
AB  - Human leukocyte antigen (HLA) genes are candidates for susceptibility genes in 
      insulin-dependent diabetes mellitus (IDDM). Recently, the association of DR and 
      DQ with IDDM has been reported, but the role of HLA-DP genes remains uncertain. 
      To address the question, we analyzed the DPB1 gene of 20 Japanese IDDM patients 
      and 30 control subjects using a combination of polymerase chain reaction (PCR) 
      and restriction fragment length polymorphism (RFLP) analysis (PCR-RFLP method). 
      DPB1*0501 was the most frequent allele both in Japanese patients and control 
      subjects. There was no appreciable association between IDDM and the DPB1 allele 
      in Japanese. The absence of association between IDDM and DP, in spite of the 
      known association between this disease and both DR and DQ, suggests that the HLA 
      locus (loci) telomeric to DP encodes susceptibility to IDDM.
FAU - Yamagata, K
AU  - Yamagata K
AD  - Second Department of Internal Medicine, Osaka University Medical School, Japan.
FAU - Hanafusa, T
AU  - Hanafusa T
FAU - Nakajima, H
AU  - Nakajima H
FAU - Sada, M
AU  - Sada M
FAU - Amemiya, H
AU  - Amemiya H
FAU - Tomita, K
AU  - Tomita K
FAU - Miyagawa, J
AU  - Miyagawa J
FAU - Noguchi, T
AU  - Noguchi T
FAU - Tanaka, T
AU  - Tanaka T
FAU - Kono, N
AU  - Kono N
AU  - et al.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-DP Antigens)
SB  - IM
GS  - DPB1
MH  - Alleles
MH  - Autoimmune Diseases/*genetics/immunology
MH  - Base Sequence
MH  - Diabetes Mellitus, Type 1/*genetics/immunology
MH  - Disease Susceptibility/immunology
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - HLA-DP Antigens/*analysis/genetics
MH  - Humans
MH  - Japan
MH  - Molecular Sequence Data
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Restriction Fragment Length
EDAT- 1991/09/01 00:00
MHDA- 1991/09/01 00:01
CRDT- 1991/09/01 00:00
PHST- 1991/09/01 00:00 [pubmed]
PHST- 1991/09/01 00:01 [medline]
PHST- 1991/09/01 00:00 [entrez]
AID - 10.1111/j.1399-0039.1991.tb02022.x [doi]
PST - ppublish
SO  - Tissue Antigens. 1991 Sep;38(3):107-10. doi: 10.1111/j.1399-0039.1991.tb02022.x.