PMID- 16866886
OWN - NLM
STAT- MEDLINE
DCOM- 20060818
LR  - 20221207
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 68
IP  - 2
DP  - 2006 Aug
TI  - Diversity of human leukocyte antigen-B27 alleles in Han population of Hunan 
      province, southern China.
PG  - 163-6
AB  - This study was to investigate the frequency of HLA-B27 and its subtypes in the 
      Han population of Hunan province, southern China. One hundred and sixty-nine 
      healthy unrelated donors were tested for HLA-B27 by polymerase chain 
      reaction-sequence-specific primer (PCR-SSP). One hundred and twenty-eight 
      B27-positive spondyloarthropathy patients and 18 B27-positive healthy controls 
      were subtyped using the high-resolution PCR-SSP. The phenotype frequency of human 
      leukocyte antigen (HLA)-B27 was found to be 2.36% in healthy population. Five B27 
      alleles were identified: B*2704, B*2705, B*2706, B*2707, and B*2724. No 
      significant difference was found in the distribution of HLA-B27 subtypes between 
      the patients and controls studied. Notably, B*2724 was observed in a juvenile 
      patient with ankylosing spondylitis. This subtype has not been previously 
      reported in Chinese ankylosing spondylitis (AS) patients and other ethnic groups.
FAU - Ma, H-J
AU  - Ma HJ
AD  - Department of Immunology, Xiangya School of Medicine, Central South University, 
      Changsha 410078, Hunan, China.
FAU - Hu, F-P
AU  - Hu FP
LA  - eng
PT  - Journal Article
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-B27 Antigen)
SB  - IM
MH  - Asian People/*genetics
MH  - Case-Control Studies
MH  - China
MH  - Ethnicity/genetics
MH  - Genetic Predisposition to Disease
MH  - HLA-B27 Antigen/*genetics
MH  - Humans
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Genetic
MH  - Spondylitis, Ankylosing/*genetics
EDAT- 2006/07/27 09:00
MHDA- 2006/08/19 09:00
CRDT- 2006/07/27 09:00
PHST- 2006/07/27 09:00 [pubmed]
PHST- 2006/08/19 09:00 [medline]
PHST- 2006/07/27 09:00 [entrez]
AID - TAN638 [pii]
AID - 10.1111/j.1399-0039.2006.00638.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2006 Aug;68(2):163-6. doi: 10.1111/j.1399-0039.2006.00638.x.