PMID- 16869343
OWN - NLM
STAT- MEDLINE
DCOM- 20060809
LR  - 20220310
IS  - 0012-6667 (Print)
IS  - 0012-6667 (Linking)
VI  - 66 Suppl 1
DP  - 2006
TI  - Non-erosive reflux disease and atypical gastro-oesophageal reflux disease 
      manifestations: treatment results.
PG  - 7-13; discussion 29-33
AB  - Gastro-oesophageal reflux disease (GERD) is a widespread complex disorder that 
      may be responsible for a variety of different symptoms and clinical features. 
      Despite the presence of symptoms, the majority of patients do not have endoscopic 
      lesions of oesophagitis. Non-erosive reflux disease (NERD) is a chronic, 
      relapsing condition that can adversely affect the quality of life despite the 
      absence of mucosal breaks at endoscopy. In many patients GERD is associated with 
      extra-oesophageal or atypical manifestations, including cough, asthma, laryngitis 
      or non-cardiac chest pain. Acid suppression with proton pump inhibitors (PPI) 
      remains the mainstay of GERD therapy. However, patients with NERD and 
      extra-oesophageal manifestations are often poorly responsive to PPI therapy. 
      Accurate diagnosis followed by adequate PPI dosage and compliance with therapy 
      are essential for the successful control of NERD and extra-oesophageal 
      manifestations. The better detection and characterization of acid and non-acid 
      reflux episodes using developing technologies, such as combined pH-impedance 
      monitoring, is extending our understanding of the pathophysiology of NERD and the 
      extra-oesophageal manifestations of GERD, and will lead to the improved 
      management of these often poorly responsive conditions. This article reviews the 
      treatment results and outlines approaches to the evaluation, diagnosis and 
      therapy of NERD and atypical GERD manifestations.
FAU - Galmiche, Jean Paul
AU  - Galmiche JP
AD  - Department of Gastroenterology and Hepatology, CIC INSERM-CHU, Nantes University, 
      France. jeanpaul.galmiche@chu-nantes.fr
LA  - eng
PT  - Journal Article
PT  - Review
PL  - New Zealand
TA  - Drugs
JT  - Drugs
JID - 7600076
SB  - IM
MH  - Asthma/etiology
MH  - Chest Pain/etiology
MH  - Cough/etiology
MH  - Gastroesophageal Reflux/*complications/therapy
MH  - Humans
MH  - Laryngitis/etiology
RF  - 24
EDAT- 2006/07/28 09:00
MHDA- 2006/08/10 09:00
CRDT- 2006/07/28 09:00
PHST- 2006/07/28 09:00 [pubmed]
PHST- 2006/08/10 09:00 [medline]
PHST- 2006/07/28 09:00 [entrez]
AID - 10.2165/00003495-200666001-00003 [doi]
PST - ppublish
SO  - Drugs. 2006;66 Suppl 1:7-13; discussion 29-33. doi: 
      10.2165/00003495-200666001-00003.