PMID- 16869771
OWN - NLM
STAT- MEDLINE
DCOM- 20060908
LR  - 20240503
IS  - 0091-7451 (Print)
IS  - 1943-4456 (Electronic)
IS  - 0091-7451 (Linking)
VI  - 70
DP  - 2005
TI  - Microenvironmental regulators of tissue structure and function also regulate 
      tumor induction and progression: the role of extracellular matrix and its 
      degrading enzymes.
PG  - 343-56
AB  - It is now widely accepted that elements of the cellular and tissue 
      microenvironment are crucial regulators of cell behavior in culture and 
      homeostasis in vivo, and that many of the same factors influence the course of 
      tumor progression. Less well established is the extent to which extracellular 
      factors actually cause cancer, and the circumstances under which this may occur. 
      Using physiologically relevant three-dimensional culture assays and transgenic 
      animals, we have explored how the environmental and architectural context of 
      cells, tissues, and organs controls mammary-specific gene expression, growth 
      regulation, apoptosis, and drug resistance and have found that loss of tissue 
      structure is a prerequisite for cancer progression. Here we summarize this 
      evidence and highlight two of our recent studies. Using mouse mammary epithelial 
      cells, we show that exposure to matrix metalloproteinase-3 (MMP-3) stimulates 
      production of reactive oxygen species (ROS) that destabilize the genome and 
      induce epithelial-mesenchymal transition, causing malignant transformation. Using 
      a human breast cancer progression series, we find that ADAM-dependent growth 
      factor shedding plays a crucial role in acquisition of the malignant phenotype. 
      These findings illustrate how normal tissue structure controls the response to 
      extracellular signals so as to preserve tissue specificity and growth status.
FAU - Bissell, M J
AU  - Bissell MJ
AD  - Cancer Biology Department, Life Sciences Division, Lawrence Berkeley National 
      Laboratory, University of California, 94720, USA.
FAU - Kenny, P A
AU  - Kenny PA
FAU - Radisky, D C
AU  - Radisky DC
LA  - eng
GR  - 2 R01 CA064786-09/CA/NCI NIH HHS/United States
GR  - R01 CA064786-09/CA/NCI NIH HHS/United States
GR  - R01 CA057621/CA/NCI NIH HHS/United States
GR  - CA57621/CA/NCI NIH HHS/United States
GR  - R01 CA064786/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Cold Spring Harb Symp Quant Biol
JT  - Cold Spring Harbor symposia on quantitative biology
JID - 1256107
RN  - EC 3.4.- (Metalloproteases)
SB  - IM
MH  - Animals
MH  - Breast/pathology/physiopathology
MH  - Breast Neoplasms/etiology/pathology/physiopathology
MH  - Cell Shape
MH  - Cell Transformation, Neoplastic
MH  - Extracellular Matrix/enzymology/pathology/*physiology
MH  - Female
MH  - Humans
MH  - Mammary Glands, Animal/pathology/physiopathology
MH  - Mammary Neoplasms, Experimental/etiology/pathology/physiopathology
MH  - Metalloproteases/genetics
MH  - Mice
MH  - Neoplasms/*etiology/pathology/physiopathology
MH  - Oncogenes
MH  - Polymorphism, Genetic
MH  - Signal Transduction
PMC - PMC3004779
MID - NIHMS255060
EDAT- 2006/07/28 09:00
MHDA- 2006/09/09 09:00
PMCR- 2010/12/20
CRDT- 2006/07/28 09:00
PHST- 2006/07/28 09:00 [pubmed]
PHST- 2006/09/09 09:00 [medline]
PHST- 2006/07/28 09:00 [entrez]
PHST- 2010/12/20 00:00 [pmc-release]
AID - 10.1101/sqb.2005.70.013 [doi]
PST - ppublish
SO  - Cold Spring Harb Symp Quant Biol. 2005;70:343-56. doi: 10.1101/sqb.2005.70.013.