PMID- 16870508
OWN - NLM
STAT- MEDLINE
DCOM- 20061205
LR  - 20220311
IS  - 1471-4906 (Print)
IS  - 1471-4906 (Linking)
VI  - 27
IP  - 9
DP  - 2006 Sep
TI  - Epigenetic regulation of MHC-II and CIITA genes.
PG  - 405-12
AB  - This review describes recent advances in understanding how epigenetic events 
      control MHC-class-II-family (MHC-II) gene expression. To address this issue, two 
      phases of gene transcription have to be considered. First, the control of MHC-II 
      by chromatin-modifying events such as histone acetylation, methylation, 
      deacetylation, ubiquitination and the interplay between these different 
      epigenetic events will be examined. The interactions of chromatin-modifying 
      enzymes with class II transactivator (CIITA) and relevant DNA-binding proteins 
      for activating and silencing MHC-II gene transcription will be reviewed. Second, 
      the transcriptional control of the promoter of CIITA, the master regulator of 
      MHC-II, by DNA methylation and chromatin modification will be discussed, and the 
      novel role of noncoding RNA will be explored. Finally, the relevance of these 
      findings to infection, transplantation and cancer will be reviewed.
FAU - Wright, Kenneth L
AU  - Wright KL
AD  - H. Lee Moffitt Cancer Center and Research Institute, and the Department of 
      Interdisciplinary Oncology, University of South Florida, Tampa, FL 33612, USA. 
      WrightKL@moffitt.usf.edu
FAU - Ting, Jenny P-Y
AU  - Ting JP
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20060725
PL  - England
TA  - Trends Immunol
JT  - Trends in immunology
JID - 100966032
RN  - 0 (MHC class II transactivator protein)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Trans-Activators)
SB  - IM
MH  - Animals
MH  - Epigenesis, Genetic/*immunology
MH  - Genes, MHC Class II/*immunology
MH  - Humans
MH  - Nuclear Proteins/*genetics/immunology
MH  - Trans-Activators/*genetics/immunology
RF  - 65
EDAT- 2006/07/28 09:00
MHDA- 2006/12/09 09:00
CRDT- 2006/07/28 09:00
PHST- 2006/06/02 00:00 [received]
PHST- 2006/06/23 00:00 [revised]
PHST- 2006/07/12 00:00 [accepted]
PHST- 2006/07/28 09:00 [pubmed]
PHST- 2006/12/09 09:00 [medline]
PHST- 2006/07/28 09:00 [entrez]
AID - S1471-4906(06)00217-1 [pii]
AID - 10.1016/j.it.2006.07.007 [doi]
PST - ppublish
SO  - Trends Immunol. 2006 Sep;27(9):405-12. doi: 10.1016/j.it.2006.07.007. Epub 2006 
      Jul 25.