PMID- 16871018
OWN - NLM
STAT- MEDLINE
DCOM- 20061024
LR  - 20190608
IS  - 1229-845X (Print)
IS  - 1976-555X (Electronic)
IS  - 1229-845X (Linking)
VI  - 7
IP  - 3
DP  - 2006 Sep
TI  - Efficacy of VP2 protein expressed in E. coli for protection against highly 
      virulent infectious bursal disease virus.
PG  - 241-7
AB  - The ability of a heat-inactivated whole virus from a highly virulent infectious 
      bursal disease virus (hvIBDV) and VP2 protein from hvIBDV expressed in E. coli 
      provided protection against a hvIBDV challenge in specificpathogen-free (SPF) 
      chickens. Six out of seven chickens that were injected three times with crude VP2 
      protein developed significant antibody titer against IBDV. However, only four out 
      of the seven chickens survived the hvIBDV challenge. Despite showing low antibody 
      titer profiles, all chickens immunized with the heat-inactivated whole virus also 
      survived the challenged with hvIBDV. However, all of these chickens had bursal 
      atrophy and mild to moderate depletion of lymphocytes. Thus, antibodies raised 
      against IBDV VP2 protein expressed in E. coli and denatured IBDV proteins induced 
      some degree of protection against mortality but not against bursal damage 
      following challenge with hvIBDV.
FAU - Omar, Abdul Rahman
AU  - Omar AR
AD  - Institute of Bioscience, University Putra Malaysia, 43400 UPM Serdang, Selangor 
      Darul Ehsan, Malaysia. aro@ibs.upm.edu.my
FAU - Kim, Chong Lee
AU  - Kim CL
FAU - Bejo, Mohd Hair
AU  - Bejo MH
FAU - Ideris, Aini
AU  - Ideris A
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - Korea (South)
TA  - J Vet Sci
JT  - Journal of veterinary science
JID - 100964185
RN  - 0 (Antibodies, Viral)
RN  - 0 (Recombinant Proteins)
RN  - 0 (VP2 protein, infectious bursal disease virus)
RN  - 0 (Vaccines, Attenuated)
RN  - 0 (Vaccines, Synthetic)
RN  - 0 (Viral Structural Proteins)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - Antibodies, Viral/blood
MH  - Birnaviridae Infections/immunology/prevention & control/*veterinary/virology
MH  - Chickens
MH  - Enzyme-Linked Immunosorbent Assay/veterinary
MH  - Escherichia coli/genetics
MH  - Immunization/standards/*veterinary
MH  - Infectious bursal disease virus/genetics/*immunology/pathogenicity
MH  - Poultry Diseases/*immunology/prevention & control/virology
MH  - Recombinant Proteins/genetics/*immunology
MH  - Specific Pathogen-Free Organisms
MH  - Vaccines, Attenuated/immunology/pharmacology
MH  - Vaccines, Synthetic/immunology/pharmacology
MH  - Viral Structural Proteins/biosynthesis/genetics/*immunology
MH  - Viral Vaccines/*immunology/pharmacology
PMC - PMC3242123
EDAT- 2006/07/28 09:00
MHDA- 2006/10/25 09:00
PMCR- 2006/09/01
CRDT- 2006/07/28 09:00
PHST- 2006/07/28 09:00 [pubmed]
PHST- 2006/10/25 09:00 [medline]
PHST- 2006/07/28 09:00 [entrez]
PHST- 2006/09/01 00:00 [pmc-release]
AID - 200609241 [pii]
AID - 10.4142/jvs.2006.7.3.241 [doi]
PST - ppublish
SO  - J Vet Sci. 2006 Sep;7(3):241-7. doi: 10.4142/jvs.2006.7.3.241.