PMID- 1687169
OWN - NLM
STAT- MEDLINE
DCOM- 19920504
LR  - 20190712
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 40
IP  - 2
DP  - 1991 Oct
TI  - MDMA produces a conditioned place preference and elicits ejaculation in male 
      rats: a modulatory role for the endogenous opioids.
PG  - 443-7
AB  - Methylenedioxymethamphetamine (MDMA) can produce a conditioned place preference 
      (CPP) among rats. The ability of MDMA to produce a CPP was assessed while some 
      rats were under the influence of naltrexone, 56 mg/kg, given 4 h before 
      conditioning. Naltrexone attenuated MDMA's ability to produce a CPP without 
      completely blocking MDMA's effects. Having noticed previously the production of 
      seminal plugs by rats receiving MDMA, the presence of seminal plugs was recorded 
      across the 8 days of conditioning. Roughly half of the rats receiving 6.3 mg/kg 
      of MDMA left plugs during the conditioning period, while over two-thirds of those 
      receiving a combination of MDMA and naltrexone left plugs. A second study, 
      assessing further doses of MDMA, tabulated the drug's effects on the production 
      of seminal plugs across 3 h. Besides eliciting ejaculation, MDMA also led to 
      increased urination and defecation and a loss of body weight. These results 
      support suggestions that the endogenous opioids modulate the reinforcing 
      properties of stimulant drugs and affect male sexuality.
FAU - Bilsky, E J
AU  - Bilsky EJ
AD  - Department of Psychology, Rensselaer Polytechnic Institute, Troy, NY 12180.
FAU - Hubbell, C L
AU  - Hubbell CL
FAU - Delconte, J D
AU  - Delconte JD
FAU - Reid, L D
AU  - Reid LD
LA  - eng
GR  - DA04440/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Endorphins)
RN  - 0 (Serotonin Antagonists)
RN  - 0 (Tropanes)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - 5S6W795CQM (Naltrexone)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - O98T3677PA (bemesetron)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*analogs & derivatives/pharmacology
MH  - Animals
MH  - Conditioning, Operant/*drug effects
MH  - Defecation/drug effects
MH  - Ejaculation/*drug effects
MH  - Endorphins/*physiology
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Naltrexone/pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Serotonin Antagonists/pharmacology
MH  - Tropanes/pharmacology
MH  - Urination/drug effects
EDAT- 1991/10/01 00:00
MHDA- 1991/10/01 00:01
CRDT- 1991/10/01 00:00
PHST- 1991/10/01 00:00 [pubmed]
PHST- 1991/10/01 00:01 [medline]
PHST- 1991/10/01 00:00 [entrez]
AID - 0091-3057(91)90577-O [pii]
AID - 10.1016/0091-3057(91)90577-o [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 1991 Oct;40(2):443-7. doi: 10.1016/0091-3057(91)90577-o.