PMID- 16872586
OWN - NLM
STAT- MEDLINE
DCOM- 20061031
LR  - 20191210
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 1109
IP  - 1
DP  - 2006 Sep 13
TI  - Protective effect of N-acetyl-L-cysteine on amyloid beta-peptide-induced learning 
      and memory deficits in mice.
PG  - 201-6
AB  - This study aimed to examine the effects of N-acetyl-L-cysteine (NAC) on 
      protecting neurons function and improving learning and memory deficits in mice. 
      Mice were intracerebroventricularly (icv) injected with the aggregated amyloid 
      beta-peptide (Abeta) to produce Alzheimer's disease (AD). Learning and memory 
      functions in mice were examined by the step through test and the water maze 
      performance. The results showed that the mice pretreated with NAC had 
      significantly greater retention in the step through test and shorter latencies in 
      the water maze performance. Biochemical studies showed the potential role of free 
      radical toxicity and the damage of cholinergic neurons in the Abeta-treated mice. 
      There was an increased lipid peroxidation as indicated by elevated malondehyde 
      (MDA) and decrease of glutathione (GSH) levels. There was also an increase in 
      acetylcholinesterase (AChE) activity and a reduction in the choline 
      acetyltransferase (ChAT) activity and acetylcholine (ACh) levels. NAC 
      pretreatment significantly reversed the elevated MDA, AChE and the reduced GSH, 
      ChAT and ACh in the Abeta-model mice. The results of the present study suggest 
      the potential usage of the neuroprotective action of NAC on AD.
FAU - Fu, Ai-Ling
AU  - Fu AL
AD  - Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, 
      Beijing, 100850, China.
FAU - Dong, Zhao-Hui
AU  - Dong ZH
FAU - Sun, Man-Ji
AU  - Sun MJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20060726
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Expectorants)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - EC 2.3.1.6 (Choline O-Acetyltransferase)
RN  - EC 3.1.1.7 (Acetylcholinesterase)
RN  - GAN16C9B8O (Glutathione)
RN  - N9YNS0M02X (Acetylcholine)
RN  - WYQ7N0BPYC (Acetylcysteine)
SB  - IM
MH  - Acetylcholine/metabolism
MH  - Acetylcholinesterase/metabolism
MH  - Acetylcysteine/*administration & dosage
MH  - *Amyloid beta-Peptides
MH  - Analysis of Variance
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Brain Chemistry/drug effects
MH  - Choline O-Acetyltransferase/metabolism
MH  - DNA Fragmentation/drug effects
MH  - Dose-Response Relationship, Drug
MH  - Drug Interactions
MH  - Expectorants/*administration & dosage
MH  - Glutathione/metabolism
MH  - Hippocampus/drug effects/pathology
MH  - Injections, Intraventricular/methods
MH  - Learning Disabilities/chemically induced/*prevention & control
MH  - Lipid Peroxidation/drug effects
MH  - Male
MH  - Malondialdehyde/metabolism
MH  - Mice
MH  - Mice, Inbred Strains
EDAT- 2006/07/29 09:00
MHDA- 2006/11/01 09:00
CRDT- 2006/07/29 09:00
PHST- 2006/05/02 00:00 [received]
PHST- 2006/06/14 00:00 [revised]
PHST- 2006/06/15 00:00 [accepted]
PHST- 2006/07/29 09:00 [pubmed]
PHST- 2006/11/01 09:00 [medline]
PHST- 2006/07/29 09:00 [entrez]
AID - S0006-8993(06)01867-1 [pii]
AID - 10.1016/j.brainres.2006.06.042 [doi]
PST - ppublish
SO  - Brain Res. 2006 Sep 13;1109(1):201-6. doi: 10.1016/j.brainres.2006.06.042. Epub 
      2006 Jul 26.