PMID- 16874703
OWN - NLM
STAT- MEDLINE
DCOM- 20060928
LR  - 20211203
IS  - 1121-8428 (Print)
IS  - 1121-8428 (Linking)
VI  - 19
IP  - 3
DP  - 2006 May-Jun
TI  - Henoch-Schonlein purpura and Crohn's disease in a family.
PG  - 387-90
AB  - A 16-year-old female who underwent an appendicectomy had terminal segmental 
      ileitis, and developed Henoch-Schonlein purpura (HSP) a few days later. Her 
      brother had suffered from post-infection HSP, while her mother has suffered from 
      Crohn's disease. Human leukocyte antigen (HLA) typing in the patient disclosed 
      the DRB1*11 allele, which has been reported to be associated with HSP, but the 
      brother proved negative, suggesting that this allele was irrelevant to the HSP 
      pathogenesis. The patient and the other relatives did not disclose HLA DRB1*01, 
      which is the only class II phenotype reported to be associated with both 
      diseases. While this case report lends support to the idea that the earlier 
      observation of concomitant Crohn's disease and HSP in the same patients is no 
      chance association, it suggests that if the two pathological conditions share a 
      common genetic background, this does not seem to be related to class II HLA 
      phenotypes. Other, as yet unknown genes could be involved.
FAU - Cassater, Daiana
AU  - Cassater D
AD  - School of Medicine, University of Verona, Verona, Italy.
FAU - Gambaro, Giovanni
AU  - Gambaro G
FAU - Fabris, Antonia
AU  - Fabris A
FAU - Cena, Camilla
AU  - Cena C
FAU - Calabria, Stefano
AU  - Calabria S
FAU - Capelluto, Sara
AU  - Capelluto S
FAU - Lupo, Antonio
AU  - Lupo A
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Italy
TA  - J Nephrol
JT  - Journal of nephrology
JID - 9012268
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Crohn Disease/*complications/genetics
MH  - Female
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - IgA Vasculitis/*complications/genetics
EDAT- 2006/07/29 09:00
MHDA- 2006/09/29 09:00
CRDT- 2006/07/29 09:00
PHST- 2006/07/29 09:00 [pubmed]
PHST- 2006/09/29 09:00 [medline]
PHST- 2006/07/29 09:00 [entrez]
PST - ppublish
SO  - J Nephrol. 2006 May-Jun;19(3):387-90.