PMID- 16875552
OWN - NLM
STAT- MEDLINE
DCOM- 20090202
LR  - 20060731
IS  - 0253-2727 (Print)
IS  - 0253-2727 (Linking)
VI  - 27
IP  - 4
DP  - 2006 Apr
TI  - [The significance of IGF-1, VEGF, IL-6 in multiple myeloma progression].
PG  - 231-4
AB  - OBJECTIVE: To study the alteration and significance of IL-6, vascular endothelial 
      growth factor (VEGF), insulin-like growth factor-1 (IGF-1) in MM progression and 
      the interaction between the three cytokines. METHODS: Bone marrow samples from 28 
      patients with multiple myeloma (MM) (evolution group and steady group), 10 iron 
      deficiency anemia (as normal control) and 2 monoclonal gammopathy of undetermined 
      significance (MGUS) were studied. Bone marrow stromal cells (BMSCs) were 
      established from the bone marrow MNCs. ELISA was performed to detect the 
      concentration of IL-6, VEGF, IGF-1 in culture supernates. RESULTS: (1) The levels 
      of IL-6 and VEGF secreted by BMSCs were increased in an order from normal control 
      to steady group to evolution group (P < 0.05). However, the concentration of 
      IGF-1 did not increase in MM patients (P > 0.05). (2) The levels of IL-6, VEGF 
      and IGF-1 in the coculture supernates of U266 and BMSCs were increased 
      significantly (P < 0.05), being in an ascending order from normal control to 
      steady group to evolution group (P < 0.05). (3) BMSCs stimulated by exogenous 
      IL-6, VEGF or IGF-1, secreted more VEGF, IGF-1/IL-6, IGF-1/VEGF, IL-6 than 
      unstimulated (P < 0.05). (4) The levels of IL-6, VEGF, IGF-1 secreted by BMSCs 
      from MGUS were similar to that from control group. CONCLUSIONS: IL-6, VEGF, IGF-1 
      levels associate with evolution of MM; IL-6, VEGF and IGF-1 induce an increase in 
      cytokines secretion of BMSCs.
FAU - Guo, Yi-qun
AU  - Guo YQ
AD  - Department of Hematology, Chao Yang Hospital, Capital University of Medical 
      Science, Beijing 100020, China.
FAU - Chen, Shi-lun
AU  - Chen SL
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Xue Ye Xue Za Zhi
JT  - Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
JID - 8212398
RN  - 0 (Interleukin-6)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Anemia, Iron-Deficiency/blood/pathology
MH  - Bone Marrow Cells/metabolism/pathology
MH  - Cells, Cultured
MH  - Female
MH  - Humans
MH  - Insulin-Like Growth Factor I/*metabolism
MH  - Interleukin-6/*blood
MH  - Male
MH  - Middle Aged
MH  - Multiple Myeloma/blood/*pathology
MH  - Paraproteinemias/blood/pathology
MH  - Stromal Cells/metabolism/pathology
MH  - Vascular Endothelial Growth Factor A/*blood
EDAT- 2006/08/01 09:00
MHDA- 2009/02/03 09:00
CRDT- 2006/08/01 09:00
PHST- 2006/08/01 09:00 [pubmed]
PHST- 2009/02/03 09:00 [medline]
PHST- 2006/08/01 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Xue Ye Xue Za Zhi. 2006 Apr;27(4):231-4.