PMID- 16875578
OWN - NLM
STAT- MEDLINE
DCOM- 20090126
LR  - 20060731
IS  - 0253-2727 (Print)
IS  - 0253-2727 (Linking)
VI  - 27
IP  - 5
DP  - 2006 May
TI  - [Clinical and laboratory characteristics of two acute lymphoblastic leukemia 
      patients with dicentric (9; 20) (p11 - 13; q11)].
PG  - 306-9
AB  - OBJECTIVE: To explore the morphologic, immunophenotypic, cytogenetic and clinical 
      features of acute lymphoblastic leukemia (ALL) patients with dicentric (9; 20) 
      (p11 - 13; q11). METHODS: Chromosome specimens of bone marrow cells were prepared 
      by direct method and/or short-time culture. Karyo-typing was performed by 
      R-banding technique. Dual-color fluorescence in situ hybridization (FISH) was 
      performed using both chromosome 9 classical satellite probe and chromosome 20 
      alpha-satellite probe in one patient. RESULTS: The two ALL patients were positive 
      for CD10 and HLA-DR, showing of B cell origin. Both patients had dicentric (9; 
      20): case 1 was 45, XY, der (9) t (9; 20) (p11; q11), -20[20]; case 2 was 45, XX, 
      der (9) t (9; 20) (p13; q11), t (9; 22) (q34; q11), -20[10]/46, idem, +8[16]/47, 
      idem, +8, +21[14]. Mutual translocation between chromosomes 9 and 20 of the 
      dicentric chromosome was confirmed by FISH in one patient. CONCLUSIONS: Dicentric 
      (9; 20) (p11 - 13; q11) is a rare recurring chromosome abnormality associated 
      with ALL. Because of the subtle nature of the translocation, FISH is essential 
      for the detection of this abnormality.
FAU - Gong, Sheng-lan
AU  - Gong SL
AD  - Department of Hematology, Changhai Hospital, Second Military Medical University, 
      Shanghai 200433, China.
FAU - Qiu, Hui-ying
AU  - Qiu HY
FAU - Li, Jin-ying
AU  - Li JY
FAU - Han, Feng-lai
AU  - Han FL
FAU - Song, Xian-min
AU  - Song XM
FAU - Huang, Zheng-xia
AU  - Huang ZX
FAU - Wang, Jian-min
AU  - Wang JM
LA  - chi
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Xue Ye Xue Za Zhi
JT  - Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
JID - 8212398
SB  - IM
MH  - Adult
MH  - Base Sequence
MH  - Chromosome Banding
MH  - Chromosomes, Human, Pair 20/*genetics
MH  - Chromosomes, Human, Pair 9/*genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Male
MH  - Middle Aged
MH  - Molecular Sequence Data
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics/pathology
MH  - Sequence Analysis, DNA
MH  - *Translocation, Genetic
EDAT- 2006/08/01 09:00
MHDA- 2009/01/27 09:00
CRDT- 2006/08/01 09:00
PHST- 2006/08/01 09:00 [pubmed]
PHST- 2009/01/27 09:00 [medline]
PHST- 2006/08/01 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Xue Ye Xue Za Zhi. 2006 May;27(5):306-9.