PMID- 16876162
OWN - NLM
STAT- MEDLINE
DCOM- 20060927
LR  - 20091119
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 580
IP  - 19
DP  - 2006 Aug 21
TI  - TRUSS, a tumor necrosis factor receptor-1-interacting protein, activates c-Jun 
      NH(2)-terminal kinase and transcription factor AP-1.
PG  - 4591-6
AB  - Tumor necrosis factor-alpha (TNF-alpha) induces the transcriptional activation of 
      numerous genes involved in the inflammatory response. The recently identified 
      protein TRUSS was investigated for its role in TNF-alpha-induced activation of 
      c-Jun-NH(2) terminal kinase (JNK) and transcription factor, AP-1. Ectopic 
      expression of TRUSS activated JNK and AP-1 in the absence and presence of 
      TNF-alpha stimulation. The C-terminal region of TRUSS interacted with TNF 
      receptor-associated factor-2 (TRAF2) and co-expression of dominant-inhibitory 
      TRAF2 with TRUSS inhibited AP-1 activation, suggesting that TRUSS signaling 
      occurs upstream of TRAF2. Further, a dominant-inhibitory mutant of TRUSS 
      inhibited TNF-alpha-induced AP-1 activation. These findings suggest that TRUSS 
      activates JNK in a TRAF2-dependent fashion and is involved in TNF-alpha-induced 
      AP-1 activation via JNK kinases.
FAU - Soond, Surinder M
AU  - Soond SM
AD  - Program in Cell Biology, Department of Pediatrics, National Jewish Medical and 
      Research Center, Denver, CO 80206, USA.
FAU - Terry, Jennifer L
AU  - Terry JL
FAU - Riches, David W H
AU  - Riches DW
LA  - eng
GR  - HL55549/HL/NHLBI NIH HHS/United States
GR  - HL68628/HL/NHLBI NIH HHS/United States
GR  - T32 HL07085-31/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20060713
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (TRUSS protein, mouse)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factor AP-1)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Animals
MH  - Cell Line
MH  - Electrophoretic Mobility Shift Assay
MH  - Enzyme Activation
MH  - Humans
MH  - JNK Mitogen-Activated Protein Kinases/*metabolism
MH  - Mice
MH  - Trans-Activators/metabolism/*physiology
MH  - Transcription Factor AP-1/*metabolism
MH  - Tumor Necrosis Factor-alpha/pharmacology
EDAT- 2006/08/01 09:00
MHDA- 2006/09/28 09:00
CRDT- 2006/08/01 09:00
PHST- 2006/04/20 00:00 [received]
PHST- 2006/06/01 00:00 [revised]
PHST- 2006/06/30 00:00 [accepted]
PHST- 2006/08/01 09:00 [pubmed]
PHST- 2006/09/28 09:00 [medline]
PHST- 2006/08/01 09:00 [entrez]
AID - S0014-5793(06)00844-1 [pii]
AID - 10.1016/j.febslet.2006.06.098 [doi]
PST - ppublish
SO  - FEBS Lett. 2006 Aug 21;580(19):4591-6. doi: 10.1016/j.febslet.2006.06.098. Epub 
      2006 Jul 13.