PMID- 16876209
OWN - NLM
STAT- MEDLINE
DCOM- 20061212
LR  - 20191210
IS  - 0031-9384 (Print)
IS  - 0031-9384 (Linking)
VI  - 89
IP  - 3
DP  - 2006 Oct 30
TI  - Experience-dependent changes in temperature and behavioral activity induced by 
      MDMA.
PG  - 358-63
AB  - Hyperthermia and hyperlocomotor activity are commonly reported acute effects of 
      high dose, experimenter-delivered 3,4-methylenedioxymethamphetamine (MDMA). The 
      current investigation was performed to determine short- to long-term 
      physiological and behavioral changes induced by moderate intake MDMA 
      self-administration. In the present study, rats self-administered MDMA (approx. 
      2.0-7.0 mg/kg/day) across 20 days during daily 2-h operant sessions. Locomotor 
      activity was assessed during MDMA self-administration sessions and core 
      temperatures were recorded before and after each session. Findings of the first 
      several sessions showed core temperatures significantly decreased after MDMA 
      self-administration compared to baseline and to a control group that 
      self-administered saline during operant sessions. As sessions proceeded, the 
      MDMA-induced hypothermic response diminished and core temperatures normalized, 
      then increased during the last few sessions. Also, locomotor activity during MDMA 
      self-administration sessions was initially equivalent to saline level activity, 
      but increased by day 8 to significantly greater levels. Our findings demonstrate 
      experience-dependent changes after voluntary administration of MDMA that are 
      clearly observable in temperature regulation and behavioral activity.
FAU - Reveron, Maria E
AU  - Reveron ME
AD  - College of Pharmacy, Division of Pharmacology and Toxicology, University of Texas 
      at Austin, PHAR-Pharmacology, 1 University Station A1915, Austin, TX 78712-0125, 
      USA.
FAU - Maier, Esther Y
AU  - Maier EY
FAU - Duvauchelle, Christine L
AU  - Duvauchelle CL
LA  - eng
GR  - R01 DA014640/DA/NIDA NIH HHS/United States
GR  - DA 14640/DA/NIDA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20060727
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Hallucinogens)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*drug effects/physiology
MH  - Body Temperature/*drug effects
MH  - Conditioning, Psychological/*drug effects/physiology
MH  - Dose-Response Relationship, Drug
MH  - Enterobacteriaceae Infections/microbiology
MH  - Hallucinogens/*pharmacology
MH  - Male
MH  - Motor Activity/drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Self Administration/methods
MH  - Time Factors
EDAT- 2006/08/01 09:00
MHDA- 2006/12/13 09:00
CRDT- 2006/08/01 09:00
PHST- 2006/02/08 00:00 [received]
PHST- 2006/06/21 00:00 [revised]
PHST- 2006/06/27 00:00 [accepted]
PHST- 2006/08/01 09:00 [pubmed]
PHST- 2006/12/13 09:00 [medline]
PHST- 2006/08/01 09:00 [entrez]
AID - S0031-9384(06)00288-5 [pii]
AID - 10.1016/j.physbeh.2006.06.021 [doi]
PST - ppublish
SO  - Physiol Behav. 2006 Oct 30;89(3):358-63. doi: 10.1016/j.physbeh.2006.06.021. Epub 
      2006 Jul 27.