PMID- 16876305
OWN - NLM
STAT- MEDLINE
DCOM- 20070129
LR  - 20220316
IS  - 0278-5846 (Print)
IS  - 0278-5846 (Linking)
VI  - 30
IP  - 8
DP  - 2006 Dec 30
TI  - Reduced serum levels of brain-derived neurotrophic factor in adult male patients 
      with autism.
PG  - 1529-31
AB  - BACKGROUND: The precise mechanisms underlying the pathophysiology of autism are 
      currently unknown. Given the key role of brain-derived neurotrophic factor (BDNF) 
      in brain development, we hypothesized that BDNF may play a role in the 
      pathophysiology of autism. In this study, we studied whether serum levels of BDNF 
      are altered in patients with autism. METHODS: We measured serum levels of BDNF in 
      18 adult male patients with autism and 18 age-matched healthy male control 
      subjects. RESULTS: The serum levels of BDNF in patients with autism (25.6+/-2.15 
      ng/ml (mean+/-S.D.)) were significantly (z = -4.42, p < 0.001) lower than those 
      of normal controls (61.6+/-10.9 ng/ml (mean+/-S.D.)). Nevertheless, we found no 
      correlations between BDNF levels and clinical variables in autistic patients. 
      CONCLUSIONS: This study suggests that reduced BDNF levels may play a role in the 
      pathophysiology of autism.
FAU - Hashimoto, Kenji
AU  - Hashimoto K
AD  - Division of Clinical Neuroscience, Chiba University Center for Forensic Mental 
      Health, 1-8-1 Inohana, Chiba 260-8670, Japan. hashimoto@faculty.chiba-u.jp
FAU - Iwata, Yasuhide
AU  - Iwata Y
FAU - Nakamura, Kazuhiko
AU  - Nakamura K
FAU - Tsujii, Masatsugu
AU  - Tsujii M
FAU - Tsuchiya, Kenji J
AU  - Tsuchiya KJ
FAU - Sekine, Yoshimoto
AU  - Sekine Y
FAU - Suzuki, Katsuaki
AU  - Suzuki K
FAU - Minabe, Yoshio
AU  - Minabe Y
FAU - Takei, Nori
AU  - Takei N
FAU - Iyo, Masaomi
AU  - Iyo M
FAU - Mori, Norio
AU  - Mori N
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060728
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
EIN - Prog Neuropsychopharmacol Biol Psychiatry. 2007 Mar 30;31(2):592
MH  - Adolescent
MH  - Adult
MH  - Autistic Disorder/*blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Humans
MH  - Interviews as Topic
MH  - Japan
MH  - Male
MH  - Reference Values
EDAT- 2006/08/01 09:00
MHDA- 2007/01/30 09:00
CRDT- 2006/08/01 09:00
PHST- 2006/04/06 00:00 [received]
PHST- 2006/06/21 00:00 [revised]
PHST- 2006/06/21 00:00 [accepted]
PHST- 2006/08/01 09:00 [pubmed]
PHST- 2007/01/30 09:00 [medline]
PHST- 2006/08/01 09:00 [entrez]
AID - S0278-5846(06)00281-8 [pii]
AID - 10.1016/j.pnpbp.2006.06.018 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2006 Dec 30;30(8):1529-31. doi: 
      10.1016/j.pnpbp.2006.06.018. Epub 2006 Jul 28.