PMID- 16877298
OWN - NLM
STAT- MEDLINE
DCOM- 20061024
LR  - 20181113
IS  - 1355-0284 (Print)
IS  - 1355-0284 (Linking)
VI  - 12
IP  - 3
DP  - 2006 Jun
TI  - Clinical symptoms and the odds of human T-cell lymphotropic virus type 
      1-associated myelopathy/ tropical spastic paraparesis (HAM/TSP) in healthy virus 
      carriers: application of best-fit logistic regression equation based on host 
      genotype, age, and provirus load.
PG  - 171-7
AB  - The authors have previously developed a logistic regression equation to predict 
      the odds that a human T-cell lymphotropic virus type 1 (HTLV-1)-infected 
      individual of specified genotype, age, and provirus load has HTLV-1-associated 
      myelopathy/tropical spastic paraparesis (HAM/TSP) in southern Japan. This study 
      evaluated whether this equation is useful predictor for monitoring asymptomatic 
      HTLV-1-seropositive carriers (HCs) in the same population. The authors genotyped 
      181 HCs for each HAM/TSP-associated gene (tumor necrosis factor 
      [TNF]-alpha-863A/C, stromal cell-derived factor 1 (SDF-1) +801G/A, human 
      leukocyte antigen [HLA]-A*02, HLA-Cw*08, HTLV-1 tax subgroup) and measured HTLV-1 
      provirus load in peripheral blood mononuclear cells using real-time polymerase 
      chain reaction (PCR). Finally, the odds of HAM/TSP for each subject were 
      calculated by using the equation and compared the results with clinical symptoms 
      and laboratory findings. Although no clear difference was seen between the odds 
      of HAM/TSP and either sex, family history of HAM/TSP or adult T-cell lenkemia 
      (ATL), history of blood transfusion, it was found that brisk patellar deep tendon 
      reflexes, which suggest latent central nervous system compromise, and flower 
      cell-like abnormal lymphocytes, which is the morphological characteristic of ATL 
      cells, were associated with a higher odds of HAM/TSP. The best-fit logistic 
      regression equation may be useful for detecting subclinical abnormalities in HCs 
      in southern Japan.
FAU - Nose, Hirohisa
AU  - Nose H
AD  - Department of Neurology and Geriatrics, Kagoshima University Graduate School of 
      Medical and Dental Sciences, Japan.
FAU - Saito, Mineki
AU  - Saito M
FAU - Usuku, Koichiro
AU  - Usuku K
FAU - Sabouri, Amir H
AU  - Sabouri AH
FAU - Matsuzaki, Toshio
AU  - Matsuzaki T
FAU - Kubota, Ryuji
AU  - Kubota R
FAU - Eiraku, Nobutaka
AU  - Eiraku N
FAU - Furukawa, Yoshitaka
AU  - Furukawa Y
FAU - Izumo, Shuji
AU  - Izumo S
FAU - Arimura, Kimiyoshi
AU  - Arimura K
FAU - Osame, Mitsuhiro
AU  - Osame M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurovirol
JT  - Journal of neurovirology
JID - 9508123
RN  - 0 (CXCL12 protein, human)
RN  - 0 (Chemokine CXCL12)
RN  - 0 (Chemokines, CXC)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Age Distribution
MH  - Carrier State/*epidemiology
MH  - Chemokine CXCL12
MH  - Chemokines, CXC/genetics
MH  - Female
MH  - Genetic Predisposition to Disease/epidemiology
MH  - Genotype
MH  - HLA-A Antigens/genetics
MH  - HLA-C Antigens/genetics
MH  - *Human T-lymphotropic virus 1
MH  - Humans
MH  - Japan/epidemiology
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Neurologic Examination
MH  - Odds Ratio
MH  - Paraparesis, Tropical Spastic/diagnosis/*epidemiology/*genetics
MH  - Predictive Value of Tests
MH  - Proviruses
MH  - ROC Curve
MH  - Tumor Necrosis Factor-alpha/genetics
MH  - Viral Load
EDAT- 2006/08/01 09:00
MHDA- 2006/10/25 09:00
CRDT- 2006/08/01 09:00
PHST- 2006/08/01 09:00 [pubmed]
PHST- 2006/10/25 09:00 [medline]
PHST- 2006/08/01 09:00 [entrez]
AID - R227084663206882 [pii]
AID - 10.1080/13550280600827336 [doi]
PST - ppublish
SO  - J Neurovirol. 2006 Jun;12(3):171-7. doi: 10.1080/13550280600827336.