PMID- 16877463
OWN - NLM
STAT- MEDLINE
DCOM- 20070330
LR  - 20191210
IS  - 1462-0324 (Print)
IS  - 1462-0324 (Linking)
VI  - 46
IP  - 2
DP  - 2007 Feb
TI  - Validity of the Saint George's Respiratory Questionnaire in the evaluation of the 
      health-related quality of life in patients with interstitial lung disease 
      secondary to systemic sclerosis.
PG  - 296-301
AB  - OBJECTIVES: Interstitial lung disease (ILD) profoundly affects the health-related 
      quality of life (HRQoL) in patients with systemic sclerosis (SSc). We tested the 
      validity of the Saint George's Respiratory Questionnaire (SGRQ), a lung-specific 
      HRQoL-evaluation tool, in a population of SSc patients with ILD. METHODS: 
      Twenty-eight consecutive SSc patients with a restrictive pulmonary involvement, 
      defined as a forced vital capacity <80% of the predicted, with no pulmonary 
      hypertension were considered. All the patients filled in the Medical Research 
      Council (MRC) scale for perceived breathlessness, the SGRQ and the Disability 
      Index of the Health Assessment Questionnaire (HAQ DI), and underwent evaluation 
      with complete pulmonary function testing (PFT), 6-minute walk distance (6MWD) and 
      high-resolution computed tomography (HRCT). RESULTS: The SGRQ 'activity' scores 
      inversely correlated with the 6MWD (r = -0.86, P < 0.001) and forced vital 
      capacity percentage of predicted values (r = -0.47) and directly correlated with 
      HRCT (r = 0.41, P < 0.05), MRC (rho = 0.64, P < 0.001) or HAQ DI scores (r = 
      0.62, P < 0.001), independently of disease duration or subset. On the contrary, 
      HAQ DI scores were influenced by those variables and corrected correlations with 
      6MWD (r = 0.56, P < 0.001) or HRCT scores (r = 0.36, P = NS) were less strong 
      than those observed with the SGRQ. CONCLUSIONS: The SGRQ, although not 
      specifically designed for scleroderma, is a valid respiratory-specific 
      questionnaire for the evaluation of HRQoL in patients with SSc-related ILD. The 
      SGRQ performs better in relation to exercise capacity and lung imaging than other 
      non-respiratory-specific questionnaires widely used in scleroderma studies. 
      Further studies are needed to address its ability to assess changes over time or 
      in response to therapy.
FAU - Beretta, L
AU  - Beretta L
AD  - Centro di Riferimento per le Malattie Autoimmuni Sistemiche, Fondazione IRCCS, 
      Policlinico-Mangaigalli-Regina Elena, Ospedale Maggiore di Milano, 20122, Via 
      Pace 9, Milano, Italy. lorberimm@hotmail.com
FAU - Santaniello, A
AU  - Santaniello A
FAU - Lemos, A
AU  - Lemos A
FAU - Masciocchi, M
AU  - Masciocchi M
FAU - Scorza, R
AU  - Scorza R
LA  - eng
PT  - Journal Article
PT  - Validation Study
DEP - 20060728
PL  - England
TA  - Rheumatology (Oxford)
JT  - Rheumatology (Oxford, England)
JID - 100883501
SB  - IM
MH  - Adult
MH  - Disability Evaluation
MH  - Exercise Test
MH  - Female
MH  - *Health Status Indicators
MH  - Humans
MH  - Linear Models
MH  - Lung Diseases, Interstitial/*etiology/physiopathology/*rehabilitation
MH  - Male
MH  - Middle Aged
MH  - *Quality of Life
MH  - Respiratory Physiological Phenomena
MH  - Scleroderma, Systemic/*complications
MH  - Severity of Illness Index
MH  - Surveys and Questionnaires
EDAT- 2006/08/01 09:00
MHDA- 2007/03/31 09:00
CRDT- 2006/08/01 09:00
PHST- 2006/08/01 09:00 [pubmed]
PHST- 2007/03/31 09:00 [medline]
PHST- 2006/08/01 09:00 [entrez]
AID - kel221 [pii]
AID - 10.1093/rheumatology/kel221 [doi]
PST - ppublish
SO  - Rheumatology (Oxford). 2007 Feb;46(2):296-301. doi: 10.1093/rheumatology/kel221. 
      Epub 2006 Jul 28.