PMID- 16878437
OWN - NLM
STAT- MEDLINE
DCOM- 20061120
LR  - 20190608
IS  - 0301-0430 (Print)
IS  - 0301-0430 (Linking)
VI  - 66
IP  - 1
DP  - 2006 Jul
TI  - Rescue treatment for cyclosporine-associated hemolytic-uremic syndrome with 
      intravenous immunoglobulin.
PG  - 58-62
AB  - Hemolytic-uremic syndrome (HUS) is a rare complication occurring in solid-organ 
      and bone marrow transplant recipients treated with calcineurin inhibitors 
      cyclosporine or tacrolimus. We report here about a 30-year-old female cadaveric 
      renal transplant recipient receiving cyclosporine who developed HUS in the early 
      post-transplant period. Renal allograft biopsy specimens showed the 
      characteristic features of thrombotic microangiopathy and acute cyclosporine 
      nephrotoxicity. Cyclosporine was discontinued and the patient was switched to 
      tacrolimus in conjunction with plasma exchange. Unfortunately, plasma exchange 
      was interrupted by bleeding complication resulting from placement of double-lumen 
      catheter. Intravenous immunoglobulin (IVIG) was then administrated as an 
      alternative therapy. Hematological resolution occurred promptly and renal 
      function recovered uneventfully. Our presenting case suggests the beneficial 
      effect of IVIG on cyclosporine-associated HUS.
FAU - Wen, Y K
AU  - Wen YK
AD  - Division of Nephrology, Department of Medicine, Changhua Christian, Hospital, 135 
      Nansiao St., Changhua, 500, Taiwan. 45440@cch.org.tw
FAU - Chen, M L
AU  - Chen ML
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Germany
TA  - Clin Nephrol
JT  - Clinical nephrology
JID - 0364441
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (Immunosuppressive Agents)
RN  - 83HN0GTJ6D (Cyclosporine)
RN  - WM0HAQ4WNM (Tacrolimus)
SB  - IM
MH  - Adult
MH  - Cyclosporine/*adverse effects
MH  - Female
MH  - Hemolytic-Uremic Syndrome/*chemically induced/pathology/*therapy
MH  - Humans
MH  - Immunoglobulins, Intravenous/*therapeutic use
MH  - Immunosuppressive Agents/*adverse effects/therapeutic use
MH  - Kidney Transplantation
MH  - Plasma Exchange
MH  - Tacrolimus/therapeutic use
EDAT- 2006/08/02 09:00
MHDA- 2006/12/09 09:00
CRDT- 2006/08/02 09:00
PHST- 2006/08/02 09:00 [pubmed]
PHST- 2006/12/09 09:00 [medline]
PHST- 2006/08/02 09:00 [entrez]
AID - 10.5414/cnp66058 [doi]
PST - ppublish
SO  - Clin Nephrol. 2006 Jul;66(1):58-62. doi: 10.5414/cnp66058.