PMID- 16879870
OWN - NLM
STAT- MEDLINE
DCOM- 20070129
LR  - 20191210
IS  - 0165-1781 (Print)
IS  - 0165-1781 (Linking)
VI  - 143
IP  - 2-3
DP  - 2006 Aug 30
TI  - Prepulse inhibition and P50 suppression: commonalities and dissociations.
PG  - 147-58
AB  - Patients with schizophrenia exhibit reduced levels of both prepulse inhibition of 
      the startle reflex (PPI) and condition-test suppression of the P50 event-related 
      potential. This study investigated the extent to which PPI and P50 suppression, 
      which exhibit similar parametric sensitivities, are intrinsically auditory 
      phenomena or can be induced cross-modally, and reflect common or distinct neural 
      mechanisms of inhibition. PPI, N100, and P50 were assessed in 20 healthy male 
      volunteers, using auditory test probes and both visual and auditory lead stimuli, 
      separated by 100- or 500-ms interstimulus intervals (ISIs). PPI was found in the 
      auditory-lead condition across the complete group, and with visual-lead stimuli 
      in approximately half of the subjects. Intra-modal auditory PPI was significantly 
      higher with the 100-ms ISI than with the 500-ms ISI. P50 suppression was found 
      only with the 500-ms ISI, with no difference between the auditory and visual 
      conditions. Source analyses revealed that suppression was associated with frontal 
      cortical activity. N100 suppression was found only in the auditory condition, 
      with no difference between 100- and 500-ms ISIs. Although both phenomena are 
      considered to provide operational measures of gating, PPI and P50 suppression are 
      differentially sensitive to ISI and therefore reflect partly different neural 
      mechanisms. They are not intrinsically auditory phenomena, and both appear to 
      involve frontal cortical activity. In contrast, N100 suppression is most likely 
      based on refractory mechanisms intrinsic to the auditory system.
FAU - Oranje, Bob
AU  - Oranje B
AD  - Center for Neuropsychiatric Schizophrenia Research, Department of Psychiatry, 
      Bispebjerg University Hospital, Bispebjerg Bakke 23, 2400 Copenhagen NV, Denmark. 
      B.Orange@cnsr.dk
FAU - Geyer, Mark A
AU  - Geyer MA
FAU - Bocker, Koen B E
AU  - Bocker KB
FAU - Leon Kenemans, J
AU  - Leon Kenemans J
FAU - Verbaten, Marinus N
AU  - Verbaten MN
LA  - eng
GR  - MH42228/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20060731
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
SB  - IM
MH  - Acoustic Stimulation
MH  - Adult
MH  - Attention/*physiology
MH  - Auditory Perception/*physiology
MH  - Brain Mapping
MH  - Cerebral Cortex/physiopathology
MH  - *Electroencephalography
MH  - Electromyography
MH  - Electrooculography
MH  - Evoked Potentials/*physiology
MH  - Frontal Lobe/physiopathology
MH  - Humans
MH  - *Inhibition, Psychological
MH  - Loudness Perception/physiology
MH  - Male
MH  - Photic Stimulation
MH  - Reaction Time/physiology
MH  - Reflex, Startle/*physiology
MH  - Schizophrenia/diagnosis/*physiopathology
MH  - Signal Processing, Computer-Assisted
MH  - Visual Perception/*physiology
EDAT- 2006/08/02 09:00
MHDA- 2007/01/30 09:00
CRDT- 2006/08/02 09:00
PHST- 2004/10/15 00:00 [received]
PHST- 2005/09/27 00:00 [revised]
PHST- 2005/11/08 00:00 [accepted]
PHST- 2006/08/02 09:00 [pubmed]
PHST- 2007/01/30 09:00 [medline]
PHST- 2006/08/02 09:00 [entrez]
AID - S0165-1781(05)00366-5 [pii]
AID - 10.1016/j.psychres.2005.11.002 [doi]
PST - ppublish
SO  - Psychiatry Res. 2006 Aug 30;143(2-3):147-58. doi: 10.1016/j.psychres.2005.11.002. 
      Epub 2006 Jul 31.