PMID- 16879899
OWN - NLM
STAT- MEDLINE
DCOM- 20070829
LR  - 20220409
IS  - 1558-1497 (Electronic)
IS  - 0197-4580 (Linking)
VI  - 28
IP  - 9
DP  - 2007 Sep
TI  - Serum neurotrophins--a study on the time course and influencing factors in a 
      large old age sample.
PG  - 1436-45
AB  - The neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor 
      (BDNF) are important mediators of brain and neuronal development, the maintenance 
      of homeostatic conditions in the adult nervous system, and the complex interplay 
      of central and peripheral physiological and pathophysiological factors. To date 
      there are few studies examining blood concentrations of neurotrophic factors in 
      large samples of healthy and diseased individuals and no published study 
      specifically addresses peripheral BDNF and NGF levels in late life. Using 
      improved highly sensitive and specific fluorometric two-site enzyme-linked 
      immunosorbent assays we examined BDNF (n=465) and NGF (n=175) serum levels in a 
      large cohort of elderly individuals (age range: 70-103 years). Neither BDNF nor 
      NGF serum levels proved to be normally distributed, indicating that previously 
      published studies with small sample sizes using parametric testing may be 
      misleading. A significant correlation was found between BDNF and platelet count 
      (r=0.344, p<0.01), age and BDNF protein (r=-0.101, p=0.029) and BDNF and NGF 
      serum levels (r=0.152, p=0.04). No other major influencing factors were found 
      including gender, depression, and dementia.
FAU - Ziegenhorn, Andreas A
AU  - Ziegenhorn AA
AD  - Department of Psychiatry, Charite Universitatsmedizin Berlin, Campus Benjamin 
      Franklin, Eschenallee 3, 14050 Berlin, Germany.
FAU - Schulte-Herbruggen, Olaf
AU  - Schulte-Herbruggen O
FAU - Danker-Hopfe, Heidi
AU  - Danker-Hopfe H
FAU - Malbranc, Monique
AU  - Malbranc M
FAU - Hartung, Heinz-Dieter
AU  - Hartung HD
FAU - Anders, Dirk
AU  - Anders D
FAU - Lang, Undine E
AU  - Lang UE
FAU - Steinhagen-Thiessen, Elisabeth
AU  - Steinhagen-Thiessen E
FAU - Schaub, Rainer T
AU  - Schaub RT
FAU - Hellweg, Rainer
AU  - Hellweg R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060801
PL  - United States
TA  - Neurobiol Aging
JT  - Neurobiology of aging
JID - 8100437
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Blood Platelets/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - *Geriatric Assessment
MH  - Humans
MH  - Nerve Growth Factor/*blood
MH  - Sex Characteristics
MH  - Statistics as Topic
MH  - Statistics, Nonparametric
MH  - Time Factors
EDAT- 2006/08/02 09:00
MHDA- 2007/08/30 09:00
CRDT- 2006/08/02 09:00
PHST- 2006/05/04 00:00 [received]
PHST- 2006/06/13 00:00 [accepted]
PHST- 2006/08/02 09:00 [pubmed]
PHST- 2007/08/30 09:00 [medline]
PHST- 2006/08/02 09:00 [entrez]
AID - S0197-4580(06)00224-7 [pii]
AID - 10.1016/j.neurobiolaging.2006.06.011 [doi]
PST - ppublish
SO  - Neurobiol Aging. 2007 Sep;28(9):1436-45. doi: 
      10.1016/j.neurobiolaging.2006.06.011. Epub 2006 Aug 1.