PMID- 16880407
OWN - NLM
STAT- MEDLINE
DCOM- 20061025
LR  - 20231213
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 103
IP  - 31
DP  - 2006 Aug 1
TI  - Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin 
      in mouse keratinocytes and trigger an atopic dermatitis.
PG  - 11736-41
AB  - We have demonstrated that cytokine thymic stromal lymphopoietin (TSLP), whose 
      expression is rapidly induced upon keratinocyte-selective ablation of retinoid X 
      receptors (RXRs) -alpha and -beta in the mouse (RXRalphabeta(ep-/-) mice), plays 
      a key role in initiating a skin and systemic atopic dermatitis-like phenotype. We 
      show here that topical application of the physiologically active ligand 
      [1alpha,25-(OH)(2)D(3); calcitriol] of the vitamin D receptor, or of its 
      low-calcemic analog MC903 (calcipotriol; Dovonex), induces TSLP expression in 
      epidermal keratinocytes, which results in an atopic dermatitis-like syndrome 
      mimicking that seen in RXRalphabeta(ep-/-) mutants and transgenic mice 
      overexpressing TSLP in keratinocytes. Furthermore, topical application of 
      retinoic acid receptor RARgamma-selective agonist BMS961 also induces TSLP 
      expression either on its own or synergistically with 1alpha,25-(OH)(2)D(3). Our 
      data demonstrate that RXR/vitamin D receptor and RXR/retinoic acid receptor-gamma 
      heterodimers and their ligands cell-autonomously control the expression of TSLP 
      in epidermal keratinocytes of the mouse. We propose molecular mechanisms through 
      which vitamin D3 and retinoic acid signalings could be involved in the 
      pathogenesis of atopic diseases.
FAU - Li, Mei
AU  - Li M
AD  - Institut de Genetique et de Biologie Moleculaire et Cellulaire and Institut 
      Clinique de la Souris, BP10142, 67404 Illkirch Cedex, France.
FAU - Hener, Pierre
AU  - Hener P
FAU - Zhang, Zhikun
AU  - Zhang Z
FAU - Kato, Shigeaki
AU  - Kato S
FAU - Metzger, Daniel
AU  - Metzger D
FAU - Chambon, Pierre
AU  - Chambon P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060731
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (BMS 961)
RN  - 0 (Cytokines)
RN  - 0 (Dermatologic Agents)
RN  - 0 (Receptors, Calcitriol)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Retinoid X Receptor alpha)
RN  - 0 (Retinoid X Receptor beta)
RN  - 0 (Retinoids)
RN  - 0 (Vitamins)
RN  - 143NQ3779B (calcipotriene)
RN  - FXC9231JVH (Calcitriol)
RN  - SY7Q814VUP (Calcium)
RN  - GT0IL38SP4 (Thymic Stromal Lymphopoietin)
SB  - IM
MH  - Administration, Topical
MH  - Animals
MH  - Calcitriol/administration & dosage/adverse effects/*analogs & 
      derivatives/immunology
MH  - Calcium/metabolism
MH  - Cells, Cultured
MH  - Cytokines/genetics/*immunology
MH  - *Dermatitis, Atopic/chemically induced/immunology
MH  - *Dermatologic Agents/administration & dosage/adverse effects/immunology
MH  - Dimerization
MH  - Female
MH  - Humans
MH  - Keratinocytes/cytology/*immunology
MH  - Mice
MH  - Mice, Knockout
MH  - Mice, Transgenic
MH  - Receptors, Calcitriol/genetics/metabolism
MH  - Receptors, Retinoic Acid/agonists/genetics/metabolism
MH  - Retinoid X Receptor alpha/agonists/genetics/metabolism
MH  - Retinoid X Receptor beta/agonists/genetics/metabolism
MH  - Retinoids/immunology
MH  - Skin/cytology/drug effects/pathology
MH  - *Vitamins/administration & dosage/adverse effects/chemistry/immunology
MH  - Thymic Stromal Lymphopoietin
MH  - Retinoic Acid Receptor gamma
PMC - PMC1544239
COIS- Conflict of interest statement: No conflicts declared.
EDAT- 2006/08/02 09:00
MHDA- 2006/10/26 09:00
PMCR- 2007/02/01
CRDT- 2006/08/02 09:00
PHST- 2006/08/02 09:00 [pubmed]
PHST- 2006/10/26 09:00 [medline]
PHST- 2006/08/02 09:00 [entrez]
PHST- 2007/02/01 00:00 [pmc-release]
AID - 0604575103 [pii]
AID - 2873 [pii]
AID - 10.1073/pnas.0604575103 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11736-41. doi: 
      10.1073/pnas.0604575103. Epub 2006 Jul 31.