PMID- 16881366 OWN - NLM STAT- MEDLINE DCOM- 20060831 LR - 20061115 IS - 0040-3660 (Print) IS - 0040-3660 (Linking) VI - 78 IP - 6 DP - 2006 TI - [Markers of inflammation--monocyte chemoattractant protein-1 (MCP-1) and C-reactive protein--in blood of patients with unstable angina pectoris and stable effort angina]. PG - 66-9 AB - AIM: To estimate concentrations of C-reactive protein (CRP) and MCP-1 in blood plasma of patients with unstable angina (UA) and stable effort angina (SEA). MATERIAL AND METHODS: Multiprojection coronaroangiography was performed in 12 patients with UA and 11 patients with SEA. Hemodynamically significant stenosis (50% and more) at least in one major coronary artery was confirmed in all the patients. CRP and MCP-1 were measured with latex agglutination and enzyme immunoassay (Biosource kits), respectively. RESULTS: UA patients had significantly higher plasma levels of MCP-1 and CRP than those with SEA (107.25 +/- 16.19 vs. 63.0 +/- 16.16 pg/ml and 1.99 +/- 1.64 vs 0.44 +/- 0.28 mcg/ml, respectively). CONCLUSION: Estimation of MCP-1, as a marker of vascular wall inflammation, can be used, in line with other indices, for verification of UA. FAU - Provatoriv, S I AU - Provatoriv SI FAU - Aref'eva, T I AU - Aref'eva TI FAU - Kukhtina, N B AU - Kukhtina NB FAU - Liukova, T K AU - Liukova TK FAU - Aref'eva, A M AU - Aref'eva AM FAU - Krasnikova, T L AU - Krasnikova TL LA - rus PT - English Abstract PT - Journal Article PL - Russia (Federation) TA - Ter Arkh JT - Terapevticheskii arkhiv JID - 2984818R RN - 0 (CCL2 protein, human) RN - 0 (Chemokine CCL2) RN - 9007-41-4 (C-Reactive Protein) SB - IM MH - Acute Disease MH - Angina Pectoris/metabolism MH - Angina, Unstable/*metabolism MH - C-Reactive Protein/*metabolism MH - Chemokine CCL2/*metabolism MH - Coronary Disease/metabolism MH - Female MH - Humans MH - Male MH - Middle Aged EDAT- 2006/08/03 09:00 MHDA- 2006/09/01 09:00 CRDT- 2006/08/03 09:00 PHST- 2006/08/03 09:00 [pubmed] PHST- 2006/09/01 09:00 [medline] PHST- 2006/08/03 09:00 [entrez] PST - ppublish SO - Ter Arkh. 2006;78(6):66-9.