PMID- 1688328
OWN - NLM
STAT- MEDLINE
DCOM- 19901114
LR  - 20190618
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 250
IP  - 4978
DP  - 1990 Oct 12
TI  - Widespread expression of BDNF but not NT3 by target areas of basal forebrain 
      cholinergic neurons.
PG  - 290-4
AB  - Brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT3) are homologs of 
      the well-known neurotrophic factor nerve growth factor. The three members of this 
      family display distinct patterns of target specificity. To examine the 
      distribution in brain of messenger RNA for these molecules, in situ hybridization 
      was performed. Cells hybridizing intensely to antisense BDNF probe were located 
      throughout the major targets of the rat basal forebrain cholinergic system, that 
      is, the hippocampus, amygdala, and neocortex. Strongly hybridizing cells were 
      also observed in structures associated with the olfactory system. The 
      distribution of NT3 mRNA in forebrain was much more limited. Within the 
      hippocampus, labeled cells were restricted to CA2, the most medial portion of 
      CA1, and the dentate gyrus. In human hippocampus, cells expressing BDNF mRNA are 
      distributed in a fashion similar to that observed in the rat. These findings 
      point to both basal forebrain cholinergic cells and olfactory pathways as 
      potential central targets for BDNF.
FAU - Phillips, H S
AU  - Phillips HS
AD  - Department of Developmental Biology, Genentech, South San Francisco, CA 94080.
FAU - Hains, J M
AU  - Hains JM
FAU - Laramee, G R
AU  - Laramee GR
FAU - Rosenthal, A
AU  - Rosenthal A
FAU - Winslow, J W
AU  - Winslow JW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (RNA Probes)
RN  - 0 (RNA, Messenger)
RN  - 0 (Sulfur Radioisotopes)
RN  - N9YNS0M02X (Acetylcholine)
SB  - IM
MH  - Acetylcholine/physiology
MH  - Animals
MH  - Autoradiography
MH  - Brain/anatomy & histology/*metabolism
MH  - Brain-Derived Neurotrophic Factor
MH  - Computer Simulation
MH  - Gene Expression
MH  - Nerve Growth Factors/*genetics
MH  - Nerve Tissue Proteins/*genetics
MH  - Neurons/*metabolism
MH  - Nucleic Acid Hybridization
MH  - Organ Specificity
MH  - RNA Probes
MH  - RNA, Messenger/*analysis/genetics
MH  - Rats
MH  - Sulfur Radioisotopes
EDAT- 1990/10/12 00:00
MHDA- 1990/10/12 00:01
CRDT- 1990/10/12 00:00
PHST- 1990/10/12 00:00 [pubmed]
PHST- 1990/10/12 00:01 [medline]
PHST- 1990/10/12 00:00 [entrez]
AID - 10.1126/science.1688328 [doi]
PST - ppublish
SO  - Science. 1990 Oct 12;250(4978):290-4. doi: 10.1126/science.1688328.