PMID- 16883637
OWN - NLM
STAT- MEDLINE
DCOM- 20061016
LR  - 20171116
IS  - 0192-415X (Print)
IS  - 0192-415X (Linking)
VI  - 34
IP  - 4
DP  - 2006
TI  - Morin promotes the production of Th2 cytokine by modulating bone marrow-derived 
      dendritic cells.
PG  - 667-84
AB  - Our previous studies had reported that morin decreased the interleukin-12 (IL-12) 
      and tumor necrosis factor-alpha (TNF-alpha) production in lipopolysaccharide 
      (LPS)-activated macrophages, suggesting that morin may promote helper T type 2 
      (Th2) response in vivo. Dendritic cells (DCs) are the most potent antigen 
      presenting cells and known to play a major role in the differentiation of helper 
      T type 1 (Th1) and Th2 responses. This study aimed to reveal whether morin is 
      able to control the Th differentiation through modulating the maturation and 
      functions of DCs. Bone marrow-derived dendritic cells (BM-DCs) were incubated 
      with various concentrations of morin and their characteristics were studied. The 
      results indicated that morin significantly affects the phenotype and cytokine 
      expression of BM-DCs. Morin reduced the production of IL-12 and TNF-alpha in 
      BM-DCs, in response to LPS stimulation. In addition, the proliferative response 
      of stimulated alloreactive T cells was significantly decreased by morin in 
      BM-DCs. Furthermore, allogeneic T cells secreted higher IL-4 and lower IFN-gamma 
      in response to morin in BM-DCs. In conclusion, these results suggested that morin 
      favors Th2 cell differentiation through modulating the maturation and function of 
      BM-DCs.
FAU - Li, Chia-Yang
AU  - Li CY
AD  - Institute of Medicine, School of Medicine, China Medical University, Taichung 
      404, Taiwan, ROC.
FAU - Suen, Jau-Ling
AU  - Suen JL
FAU - Chiang, Bor-Luen
AU  - Chiang BL
FAU - Lee Chao, Pei-Dawn
AU  - Lee Chao PD
FAU - Fang, Shih-Hua
AU  - Fang SH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Singapore
TA  - Am J Chin Med
JT  - The American journal of Chinese medicine
JID - 7901431
RN  - 0 (Antioxidants)
RN  - 0 (B7-1 Antigen)
RN  - 0 (B7-2 Antigen)
RN  - 0 (CD11c Antigen)
RN  - 0 (CD40 Antigens)
RN  - 0 (Cytokines)
RN  - 0 (Flavonoids)
RN  - 0 (Lipopolysaccharides)
RN  - 8NFQ3F76WR (morin)
SB  - IM
MH  - Animals
MH  - Antioxidants/pharmacology
MH  - B7-1 Antigen/analysis
MH  - B7-2 Antigen/analysis
MH  - Bone Marrow Cells/cytology/*drug effects/metabolism
MH  - CD11c Antigen/analysis
MH  - CD40 Antigens/analysis
MH  - Cell Differentiation/drug effects
MH  - Cell Survival/drug effects
MH  - Cytokines/*metabolism
MH  - Dendritic Cells/cytology/*drug effects/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Flavonoids/*pharmacology
MH  - Flow Cytometry
MH  - Lipopolysaccharides/pharmacology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Th2 Cells/cytology/drug effects/metabolism
MH  - Time Factors
EDAT- 2006/08/03 09:00
MHDA- 2006/10/17 09:00
CRDT- 2006/08/03 09:00
PHST- 2006/08/03 09:00 [pubmed]
PHST- 2006/10/17 09:00 [medline]
PHST- 2006/08/03 09:00 [entrez]
AID - S0192415X06004193 [pii]
AID - 10.1142/S0192415X06004193 [doi]
PST - ppublish
SO  - Am J Chin Med. 2006;34(4):667-84. doi: 10.1142/S0192415X06004193.