PMID- 16884712
OWN - NLM
STAT- MEDLINE
DCOM- 20061113
LR  - 20131121
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 545
IP  - 2-3
DP  - 2006 Sep 18
TI  - Valproate prevents MK801-induced changes in brain-derived neurotrophic factor 
      mRNA in the rat brain.
PG  - 142-6
AB  - To investigate whether the anticonvulsant valproate influences the changes in 
      brain-derived neurotrophic factor (BDNF) mRNA expression induced by MK801 in rat 
      brain, we injected valproate prior to MK801 and observed the changes in the BDNF 
      expression 3 h later. MK801 significantly increased BDNF expression in the 
      retrosplenial and entorhinal cortex, and these increases were prevented by 
      valproate pretreatment. Valproate pretreatment significantly blocked the 
      MK801-induced increase of BDNF expression in retrosplenial cortex at 3 h, 6 h, 
      and 9 h after MK801 injection, suggesting that valproate pretreatment did not 
      delay the MK801-induced increase of BDNF expression. However, MK801 significantly 
      decreased BDNF expression in the granule cell layer of hippocampus, and valproate 
      pretreatment before MK801 potentiated the MK801-induced decrease in BDNF 
      expression in granule cell layer. These results indicate that valproate 
      pretreatment differentially affects the MK801-induced changes in BDNF expression 
      in a region-selective manner.
FAU - Jeon, Gye Sun
AU  - Jeon GS
AD  - Department of Pharmacology, Korea University College of Medicine, #5 Anam-dong, 
      Seoul 136-705, South Korea.
FAU - Park, Sang-Ha
AU  - Park SH
FAU - Lee, Kuem-Ju
AU  - Lee KJ
FAU - Lee, Min-Soo
AU  - Lee MS
FAU - Chun, Boe-Gwun
AU  - Chun BG
FAU - Shin, Kyung-Ho
AU  - Shin KH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060628
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Anticonvulsants)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - 614OI1Z5WI (Valproic Acid)
RN  - 6LR8C1B66Q (Dizocilpine Maleate)
SB  - IM
MH  - Animals
MH  - Anticonvulsants/*pharmacology
MH  - Brain/*drug effects/metabolism
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Dizocilpine Maleate/*pharmacology
MH  - Male
MH  - RNA, Messenger/*analysis
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Valproic Acid/*pharmacology
EDAT- 2006/08/04 09:00
MHDA- 2006/11/14 09:00
CRDT- 2006/08/04 09:00
PHST- 2005/11/23 00:00 [received]
PHST- 2006/06/20 00:00 [revised]
PHST- 2006/06/22 00:00 [accepted]
PHST- 2006/08/04 09:00 [pubmed]
PHST- 2006/11/14 09:00 [medline]
PHST- 2006/08/04 09:00 [entrez]
AID - S0014-2999(06)00666-2 [pii]
AID - 10.1016/j.ejphar.2006.06.046 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2006 Sep 18;545(2-3):142-6. doi: 10.1016/j.ejphar.2006.06.046. 
      Epub 2006 Jun 28.