PMID- 16884911
OWN - NLM
STAT- MEDLINE
DCOM- 20061017
LR  - 20071115
IS  - 1043-4666 (Print)
IS  - 1043-4666 (Linking)
VI  - 34
IP  - 5-6
DP  - 2006 Jun
TI  - Changes in the pro-inflammatory cytokine production and peritoneal macrophage 
      function in rats with chronic heart failure.
PG  - 284-90
AB  - Chronic heart failure (CHF) is a state of immune activation, and pro-inflammatory 
      cytokines play an important role in its development and progression. Macrophages 
      (Mphis), when activated, are the main source of pro-inflammatory cytokines. We 
      measured interleukin-6 (IL-6), interleukin (IL-1beta) and tumor necrosis factor - 
      alpha (TNF-alpha) production after lipopolysaccharide (LPS)-stimulation, as well 
      as peritoneal Mphis migration, phagocytic capacity, chemotaxis index, and 
      hydrogen peroxide production, in an attempt to clarify the role of this cell in 
      an animal model of CHF. Ligature of the left coronary artery or sham operation 
      was performed in adult Wistar rats. After 12 weeks, resident and total cell 
      number, phagocytic capacity, chemotaxis index, and hydrogen peroxide production 
      in Mphis were significantly higher in CHF than in control rats. The production of 
      IL-6 and TNF- alpha was similarly significantly enhanced in CHF as compared with 
      controls. Mphis obtained from CHF rats were more responsive to LPS, suggesting 
      the existence, in vivo, of possible factor(s) modulating the production of 
      pro-inflammatory cytokines. The results demonstrated that there is modification 
      of peritoneal Mphis function along CHF development, possibly contributing to the 
      pathophysiological process in the establishment of CHF.
FAU - Batista, M L Jr
AU  - Batista ML Jr
AD  - Molecular Biology of the Cell Group, Institute of Biomedical Sciences, University 
      of Sao Paulo, Brazil. migueljr@iusp.br
FAU - Santos, R V T
AU  - Santos RV
FAU - Cunha, L M
AU  - Cunha LM
FAU - Mattos, K
AU  - Mattos K
FAU - Oliveira, E M
AU  - Oliveira EM
FAU - Seelaender, M C L
AU  - Seelaender MC
FAU - Costa Rosa, L F B P
AU  - Costa Rosa LF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060801
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (Cytokines)
RN  - 0 (Lipopolysaccharides)
SB  - IM
MH  - Animals
MH  - Blood Cell Count
MH  - Body Weight
MH  - Cytokines/*biosynthesis
MH  - Heart Failure/chemically induced/*metabolism
MH  - Inflammation/metabolism
MH  - Lipopolysaccharides/pharmacology
MH  - Macrophages, Peritoneal/cytology/drug effects/*metabolism
MH  - Male
MH  - Rats
MH  - Rats, Wistar
EDAT- 2006/08/04 09:00
MHDA- 2006/10/18 09:00
CRDT- 2006/08/04 09:00
PHST- 2006/03/29 00:00 [received]
PHST- 2006/06/06 00:00 [revised]
PHST- 2006/06/15 00:00 [accepted]
PHST- 2006/08/04 09:00 [pubmed]
PHST- 2006/10/18 09:00 [medline]
PHST- 2006/08/04 09:00 [entrez]
AID - S1043-4666(06)00188-8 [pii]
AID - 10.1016/j.cyto.2006.06.004 [doi]
PST - ppublish
SO  - Cytokine. 2006 Jun;34(5-6):284-90. doi: 10.1016/j.cyto.2006.06.004. Epub 2006 Aug 
      1.