PMID- 16884928
OWN - NLM
STAT- MEDLINE
DCOM- 20061130
LR  - 20060925
IS  - 1053-8119 (Print)
IS  - 1053-8119 (Linking)
VI  - 33
IP  - 1
DP  - 2006 Oct 15
TI  - Magnetoencephalographic study of vibrotactile evoked transient and steady-state 
      responses in human somatosensory cortex.
PG  - 252-62
AB  - Somatosensory responses to vibrotactile stimulation applied to the index 
      fingertip were recorded with whole-head MEG in eleven healthy young adult 
      participants. Stimulus trains were produced by a pneumatically driven membrane 
      oscillating at 22 Hz for a trial duration of 1 s, separated by interstimulus 
      intervals (ISIs) of 0.5, 1.0, 3.0, and 7.0 s. Data analysis was performed in two 
      frequency bands. Transient onset responses in the lower frequency band (<20 Hz) 
      contained a clearly expressed P50 component. The higher frequency band (18-30 Hz) 
      revealed a gamma-band response (GBR) within the first 200 ms followed by rhythmic 
      activity at the stimulus frequency that continued throughout the stimulus 
      duration, known as the steady-state response (SSR). Dipoles associated with the 
      transient responses and SSRs were localized in two distinct regions within the 
      primary somatosensory cortex (SI), with transient responses located on average 3 
      mm more medial and inferior than the SSRs. The transient and GBR peak amplitudes 
      increased with ISI, whereas the SSR amplitude showed no ISI dependence. These 
      results may reflect functionally and spatially distinct neural populations. 
      Further investigations are required to assess the implications of these findings 
      for probing the somatosensory system using other functional neuroimaging methods 
      such as fMRI.
FAU - Nangini, C
AU  - Nangini C
AD  - Department of Medical Biophysics, University of Toronto, ON, Canada. 
      nangini@sten.sunnybrook.utoronto.ca
FAU - Ross, B
AU  - Ross B
FAU - Tam, F
AU  - Tam F
FAU - Graham, S J
AU  - Graham SJ
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060801
PL  - United States
TA  - Neuroimage
JT  - NeuroImage
JID - 9215515
SB  - IM
MH  - Adult
MH  - Data Interpretation, Statistical
MH  - Evoked Potentials, Somatosensory/*physiology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Magnetoencephalography
MH  - Male
MH  - Mental Processes/physiology
MH  - Middle Aged
MH  - Physical Stimulation
MH  - Somatosensory Cortex/*physiology
MH  - Vibration
EDAT- 2006/08/04 09:00
MHDA- 2006/12/09 09:00
CRDT- 2006/08/04 09:00
PHST- 2006/02/17 00:00 [received]
PHST- 2006/05/26 00:00 [revised]
PHST- 2006/05/30 00:00 [accepted]
PHST- 2006/08/04 09:00 [pubmed]
PHST- 2006/12/09 09:00 [medline]
PHST- 2006/08/04 09:00 [entrez]
AID - S1053-8119(06)00654-9 [pii]
AID - 10.1016/j.neuroimage.2006.05.045 [doi]
PST - ppublish
SO  - Neuroimage. 2006 Oct 15;33(1):252-62. doi: 10.1016/j.neuroimage.2006.05.045. Epub 
      2006 Aug 1.