PMID- 16885789
OWN - NLM
STAT- MEDLINE
DCOM- 20070228
LR  - 20201209
IS  - 1529-7535 (Print)
IS  - 1529-7535 (Linking)
VI  - 7
IP  - 6
DP  - 2006 Nov
TI  - Combining lung-protective strategies in experimental acute lung injury: The 
      impact of high-frequency partial liquid ventilation.
PG  - 562-70
AB  - OBJECTIVE: To evaluate the independent and combined effects of high-frequency 
      oscillatory ventilation (HFOV) and partial liquid ventilation (PLV) on gas 
      exchange, pulmonary histopathology, inflammation, and oxidative tissue damage in 
      an animal model of acute lung injury. DESIGN: Prospective, randomized animal 
      study. SETTING: Research laboratory of a health sciences university. SUBJECTS: 
      Fifty New Zealand White rabbits. INTERVENTIONS: Juvenile rabbits injured by 
      lipopolysaccharide infusion and saline lung lavage were assigned to conventional 
      ventilation (CMV), PLV, HFOV, or high-frequency partial liquid ventilation 
      (HF-PLV) with a full or half dose (HF-PLV1/2) of perfluorochemical (PFC). 
      Uninjured ventilated animals served as controls. Arterial blood gases were 
      obtained every 30 mins during the 4-hr study. Histopathologic evaluation was 
      performed using a lung injury scoring system. Oxidative lung injury was assessed 
      by measuring malondialdehyde and 4-hydroxynonenal in lung homogenates. 
      MEASUREMENTS AND MAIN RESULTS: HFOV, PLV, or a combination of both methods 
      (HF-PLV) resulted in significantly improved oxygenation, more favorable lung 
      histopathology, reduced neutrophil infiltration, and attenuated oxidative damage 
      compared with CMV. HF-PLV with a full PFC dose did not provide any additional 
      benefit compared with HFOV alone. HF-PLV1/2 was associated with decreased 
      pulmonary leukostasis compared with HF-PLV. CONCLUSIONS: The combination of HFOV 
      and PLV (HF-PLV) does not provide any additional benefit compared with HFOV or 
      PLV alone in a combined model of lung injury when lung recruitment and volume 
      optimization can be achieved. The use of a lower PFC dose (HF-PLV1/2) is 
      associated with decreased pulmonary leukostasis compared with HF-PLV and deserves 
      further study.
FAU - Rotta, Alexandre T
AU  - Rotta AT
AD  - Department of Anesthesiology, University of Texas Medical Branch at Galveston, 
      Pediatric Critical Care, Driscoll Children's Hospital, Corpus Christi, TX, USA.
FAU - Viana, Mario Eduardo G
AU  - Viana ME
FAU - Wiryawan, Budi
AU  - Wiryawan B
FAU - Sargentelli, Guilherme A
AU  - Sargentelli GA
FAU - Dowhy, Mark S
AU  - Dowhy MS
FAU - Zin, Walter A
AU  - Zin WA
FAU - Fuhrman, Bradley P
AU  - Fuhrman BP
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Pediatr Crit Care Med
JT  - Pediatric critical care medicine : a journal of the Society of Critical Care 
      Medicine and the World Federation of Pediatric Intensive and Critical Care 
      Societies
JID - 100954653
RN  - 0 (Aldehydes)
RN  - 0 (Lipopolysaccharides)
RN  - 451W47IQ8X (Sodium Chloride)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - K1CVM13F96 (4-hydroxy-2-nonenal)
SB  - IM
MH  - Aldehydes/analysis
MH  - Animals
MH  - Blood Gas Analysis
MH  - Chest Wall Oscillation/*methods
MH  - Disease Models, Animal
MH  - Lipopolysaccharides/adverse effects
MH  - Liquid Ventilation/*methods
MH  - Lung/metabolism/pathology
MH  - Malondialdehyde/analysis
MH  - Rabbits
MH  - Respiratory Distress Syndrome/etiology/*therapy
MH  - Sodium Chloride/adverse effects
EDAT- 2006/08/04 09:00
MHDA- 2007/03/01 09:00
CRDT- 2006/08/04 09:00
PHST- 2006/08/04 09:00 [pubmed]
PHST- 2007/03/01 09:00 [medline]
PHST- 2006/08/04 09:00 [entrez]
AID - 10.1097/01.PCC.0000235250.61519.9A [doi]
PST - ppublish
SO  - Pediatr Crit Care Med. 2006 Nov;7(6):562-70. doi: 
      10.1097/01.PCC.0000235250.61519.9A.