PMID- 1688686
OWN - NLM
STAT- MEDLINE
DCOM- 19900215
LR  - 20190627
IS  - 0002-9394 (Print)
IS  - 0002-9394 (Linking)
VI  - 109
IP  - 1
DP  - 1990 Jan 15
TI  - Class II antigen expression in diabetic preretinal membranes.
PG  - 70-4
AB  - Using immunofluorescence and immunoperoxidase procedures, we found large amounts 
      of IgG, IgA, IgM, and IgE, as well as C1q, C3c, and C3d, in the connective stroma 
      and within the vascular walls on eight specimens of preretinal membranes obtained 
      from diabetic patients with proliferative retinopathy. The membranes contained 
      many isolated human leukocyte antigen (HLA) DR- and DQ-expressing cells, and 
      vascular endothelial cells strongly expressed class II determinants. Monoclonal 
      antibodies to immunocompetent cells disclosed only rare B lymphocytes or 
      suppressor/cytotoxic T cells and few monocytes. These findings confirm previous 
      evidence of immune reactions in the pars plana of patients with proliferative 
      diabetic retinopathy, and suggest that an autoimmune reaction is a factor in this 
      complication. It is yet not possible to determine whether this reaction is a 
      nonspecific consequence of the vasoproliferative processes or if it plays a 
      direct role in the development and extension of preretinal membranes.
FAU - Baudouin, C
AU  - Baudouin C
AD  - Department of Ophthalmology, Saint-Roch Hospital, Nice, France.
FAU - Gordon, W C
AU  - Gordon WC
FAU - Fredj-Reygrobellet, D
AU  - Fredj-Reygrobellet D
FAU - Baudouin, F
AU  - Baudouin F
FAU - Peyman, G
AU  - Peyman G
FAU - Gastaud, P
AU  - Gastaud P
FAU - Bazan, N G
AU  - Bazan NG
LA  - eng
GR  - EY02377/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (HLA-D Antigens)
RN  - 0 (Immunoglobulins)
RN  - 9007-36-7 (Complement System Proteins)
SB  - IM
MH  - Adult
MH  - Antibodies, Monoclonal
MH  - Autoimmune Diseases/immunology
MH  - Complement System Proteins/immunology
MH  - Diabetic Retinopathy/*etiology/immunology
MH  - Endothelium, Vascular/immunology
MH  - Female
MH  - Fluorescent Antibody Technique
MH  - HLA-D Antigens/*biosynthesis
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Immunoglobulins/immunology
MH  - Male
MH  - Membranes/immunology
MH  - Neovascularization, Pathologic
MH  - Retina/*immunology
MH  - Retinal Vessels/immunology
EDAT- 1990/01/15 00:00
MHDA- 1990/01/15 00:01
CRDT- 1990/01/15 00:00
PHST- 1990/01/15 00:00 [pubmed]
PHST- 1990/01/15 00:01 [medline]
PHST- 1990/01/15 00:00 [entrez]
AID - S0002-9394(14)75582-5 [pii]
AID - 10.1016/s0002-9394(14)75582-5 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 1990 Jan 15;109(1):70-4. doi: 10.1016/s0002-9394(14)75582-5.