PMID- 16886955
OWN - NLM
STAT- MEDLINE
DCOM- 20061121
LR  - 20060804
IS  - 0300-0664 (Print)
IS  - 0300-0664 (Linking)
VI  - 65
IP  - 2
DP  - 2006 Aug
TI  - Multiple endocrine neoplasia type 1 (MEN 1) is associated with an increased 
      prevalence of diabetes mellitus and impaired fasting glucose.
PG  - 163-8
AB  - OBJECTIVE: Multiple endocrine neoplasia type 1 (MEN 1) is an autosomal dominant 
      syndrome characterized by primary hyperparathyroidism, pituitary neoplasia and 
      foregut lineage neuroendocrine tumours. It has also been associated with 
      premature cardiovascular death. As diabetes is a risk factor for increased 
      cardiovascular mortality we investigated the prevalence and clinical correlates 
      of glycaemic abnormalities in a large MEN 1 kindred. PATIENTS AND DESIGN: The 
      glycaemic status of 72 MEN 1 affected and 133 unaffected members of a single 
      large MEN 1 pedigree was assessed. Fasting glucose results were categorized and 
      compared using WHO criteria. Associations between glycaemic status and MEN 1 
      phenotype were assessed. RESULTS: Thirteen (18.1%) patients with MEN 1 compared 
      to 5 (3.8%) control patients were diabetic (P < 0.001). Six (8.3%) MEN 1 patients 
      had impaired fasting glucose compared to 4 (3%) of controls (P < 0.05). Of 
      patients with MEN 1, uncontrolled hypercalcaemia (P < 0.05) and elevated serum 
      gastrin (P < 0.05) were more common amongst patients diagnosed with abnormal 
      glycaemia than those with normoglycaemia. There was a nonsignificant trend for 
      elevated chromogranin A, pancreatic polypeptide, gastric inhibitory polypeptide 
      (but not glucagon) and history of bronchopulmonary carcinoid in MEN 1 patients 
      with elevated glycaemia. CONCLUSIONS: Diabetes and impaired fasting glucose occur 
      significantly more frequently amongst MEN 1 patients than controls and is 
      associated with uncontrolled hyperparathyroidism and evidence of enteropancreatic 
      hyperstimulation.
FAU - McCallum, Roland W
AU  - McCallum RW
AD  - Department of Diabetes and Endocrinology, Royal Hobart Hospital, Hobart, 
      Tasmania, Australia.
FAU - Parameswaran, Venkat
AU  - Parameswaran V
FAU - Burgess, John R
AU  - Burgess JR
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Endocrinol (Oxf)
JT  - Clinical endocrinology
JID - 0346653
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Adult
MH  - Blood Glucose/*analysis
MH  - Cardiovascular Diseases/etiology
MH  - Diabetes Mellitus/*diagnosis
MH  - Epidemiologic Methods
MH  - Fasting/blood
MH  - Female
MH  - Glucose Tolerance Test
MH  - Health Surveys
MH  - Homeostasis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/blood/*complications/genetics
MH  - Pedigree
MH  - Phenotype
MH  - Risk Factors
EDAT- 2006/08/05 09:00
MHDA- 2006/12/09 09:00
CRDT- 2006/08/05 09:00
PHST- 2006/08/05 09:00 [pubmed]
PHST- 2006/12/09 09:00 [medline]
PHST- 2006/08/05 09:00 [entrez]
AID - CEN2563 [pii]
AID - 10.1111/j.1365-2265.2006.02563.x [doi]
PST - ppublish
SO  - Clin Endocrinol (Oxf). 2006 Aug;65(2):163-8. doi: 
      10.1111/j.1365-2265.2006.02563.x.