PMID- 16887138
OWN - NLM
STAT- MEDLINE
DCOM- 20070611
LR  - 20181201
IS  - 0021-9797 (Print)
IS  - 0021-9797 (Linking)
VI  - 302
IP  - 2
DP  - 2006 Oct 15
TI  - Colloidal stability of pluronic F68-coated PLGA nanoparticles: a variety of 
      stabilisation mechanisms.
PG  - 522-9
AB  - Poloxamers are a family of polypropylene oxide (PPO) and polyethylene oxide (PEO) 
      tri-block copolymers that are usually employed in the micro- and nanoparticulate 
      engineering for drug delivery systems. The aim of this work is to study the 
      electrophoretic mobility (mu(e)) and colloidal stability of complexes formed by 
      adsorbing a poloxamer (Pluronic F68) onto poly(d,l-lactic-co-glycolic acid) 
      (PLGA) nanoparticles. A variety of stabilisation mechanisms have been observed 
      for the Pluronic-coated PLGA nanoparticles, where DLVO interactions, 
      solvent-polymer segment interactions and hydration forces play different roles as 
      a function of the adsorbed amount of Pluronic. In addition, the mu(e) and 
      stability data of these complexes have been compared to those obtained previously 
      using a PLGA-Pluronic F68 blend formulation. As both the mu(e) and the stability 
      data are identical between the two systems, a phase separation of both components 
      in the PLGA-Pluronic blend formulation is suggested, being the PLGA located in 
      the core of the particles and the Pluronic in an adsorbed shell.
FAU - Santander-Ortega, M J
AU  - Santander-Ortega MJ
AD  - Biocolloid and Fluid Physics Group, Department of Applied Physics, University of 
      Granada, Av. Fuentenueva S/N, 18071, Granada, Spain.
FAU - Jodar-Reyes, A B
AU  - Jodar-Reyes AB
FAU - Csaba, N
AU  - Csaba N
FAU - Bastos-Gonzalez, D
AU  - Bastos-Gonzalez D
FAU - Ortega-Vinuesa, J L
AU  - Ortega-Vinuesa JL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060720
PL  - United States
TA  - J Colloid Interface Sci
JT  - Journal of colloid and interface science
JID - 0043125
RN  - 0 (Colloids)
RN  - 0 (Polymers)
RN  - 106392-12-5 (Poloxamer)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 451W47IQ8X (Sodium Chloride)
RN  - M4I0D6VV5M (Calcium Chloride)
SB  - IM
MH  - Adsorption
MH  - Calcium Chloride/chemistry
MH  - Colloids
MH  - Hydrogen-Ion Concentration
MH  - Lactic Acid/*chemistry
MH  - Molecular Structure
MH  - Nanoparticles/*chemistry
MH  - Particle Size
MH  - Poloxamer/*chemistry
MH  - Polyglycolic Acid/*chemistry
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Polymers/*chemistry
MH  - Sodium Chloride/chemistry
MH  - Surface Properties
EDAT- 2006/08/05 09:00
MHDA- 2007/06/15 09:00
CRDT- 2006/08/05 09:00
PHST- 2006/04/07 00:00 [received]
PHST- 2006/06/30 00:00 [revised]
PHST- 2006/07/01 00:00 [accepted]
PHST- 2006/08/05 09:00 [pubmed]
PHST- 2007/06/15 09:00 [medline]
PHST- 2006/08/05 09:00 [entrez]
AID - S0021-9797(06)00594-7 [pii]
AID - 10.1016/j.jcis.2006.07.031 [doi]
PST - ppublish
SO  - J Colloid Interface Sci. 2006 Oct 15;302(2):522-9. doi: 
      10.1016/j.jcis.2006.07.031. Epub 2006 Jul 20.