PMID- 16887298
OWN - NLM
STAT- MEDLINE
DCOM- 20061107
LR  - 20220318
IS  - 0378-1119 (Print)
IS  - 0378-1119 (Linking)
VI  - 380
IP  - 2
DP  - 2006 Oct 1
TI  - Structural organization and expression of human MTUS1, a candidate 8p22 tumor 
      suppressor gene encoding a family of angiotensin II AT2 receptor-interacting 
      proteins, ATIP.
PG  - 127-36
AB  - The Mitochondrial Tumor suppressor 1 (MTUS1) gene is a newly identified candidate 
      tumor suppressor gene at chromosomal position 8p22. We report here that MTUS1 
      encodes a family of proteins whose leader member (ATIP1) was previously isolated 
      in our laboratory as a novel interacting partner of the angiotensin II AT2 
      receptor involved in growth inhibition (Nouet, JBC 279: 28989-97, 2004). The 
      MTUS1 gene contains 17 coding exons distributed over 112 kb of genomic DNA. 
      Alternative exon usage generates three major transcripts (ATIP1, ATIP3 and 
      ATIP4), each showing different tissue distribution. ATIP polypeptides are 
      identical in their carboxy-terminal region carrying four coiled-coil domains. In 
      their amino-terminal portion, ATIP polypeptides exhibit distinct motifs for 
      localisation in the cytosol, nucleus or cell membrane, suggesting that MTUS1 gene 
      products may be involved in a variety of intracellular functions in an 
      AT2-dependent and independent manner. ATIP1 is ubiquitous and highly expressed in 
      the brain. ATIP3 is the major transcript in tissues (prostate, bladder, breast, 
      ovary, colon) corresponding to cancer types with frequent loss of heterozygosity 
      at 8p22. Interestingly, ATIP4 is a brain-specific transcript highly abundant in 
      the cerebellum and fetal brain. High evolutionary conservation of ATIP amino-acid 
      sequences suggests important biological roles for this new family of proteins in 
      tumor suppression and/or brain function.
FAU - Di Benedetto, M
AU  - Di Benedetto M
AD  - Institut Cochin, Departement de Biologie Cellulaire, Paris, F-75014, France.
FAU - Bieche, I
AU  - Bieche I
FAU - Deshayes, F
AU  - Deshayes F
FAU - Vacher, S
AU  - Vacher S
FAU - Nouet, S
AU  - Nouet S
FAU - Collura, V
AU  - Collura V
FAU - Seitz, I
AU  - Seitz I
FAU - Louis, S
AU  - Louis S
FAU - Pineau, P
AU  - Pineau P
FAU - Amsellem-Ouazana, D
AU  - Amsellem-Ouazana D
FAU - Couraud, P O
AU  - Couraud PO
FAU - Strosberg, A D
AU  - Strosberg AD
FAU - Stoppa-Lyonnet, D
AU  - Stoppa-Lyonnet D
FAU - Lidereau, R
AU  - Lidereau R
FAU - Nahmias, C
AU  - Nahmias C
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060801
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (MTUS1 protein, human)
RN  - 0 (Receptor, Angiotensin, Type 2)
RN  - 0 (Tumor Suppressor Proteins)
SB  - IM
MH  - Alternative Splicing
MH  - Base Sequence
MH  - Blotting, Northern/methods
MH  - Central Nervous System/metabolism
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 8
MH  - Evolution, Molecular
MH  - Exons
MH  - Female
MH  - Gene Expression
MH  - *Genes, Tumor Suppressor
MH  - Genetic Variation
MH  - Humans
MH  - Introns
MH  - Male
MH  - Multigene Family/genetics
MH  - Receptor, Angiotensin, Type 2/*metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction/methods
MH  - Sequence Analysis
MH  - Sequence Homology, Amino Acid
MH  - Tissue Distribution
MH  - Tumor Suppressor Proteins/chemistry/*genetics/metabolism
EDAT- 2006/08/05 09:00
MHDA- 2006/11/09 09:00
CRDT- 2006/08/05 09:00
PHST- 2006/02/27 00:00 [received]
PHST- 2006/05/05 00:00 [revised]
PHST- 2006/05/18 00:00 [accepted]
PHST- 2006/08/05 09:00 [pubmed]
PHST- 2006/11/09 09:00 [medline]
PHST- 2006/08/05 09:00 [entrez]
AID - S0378-1119(06)00350-7 [pii]
AID - 10.1016/j.gene.2006.05.021 [doi]
PST - ppublish
SO  - Gene. 2006 Oct 1;380(2):127-36. doi: 10.1016/j.gene.2006.05.021. Epub 2006 Aug 1.