PMID- 16887934
OWN - NLM
STAT- MEDLINE
DCOM- 20061204
LR  - 20220409
IS  - 0026-895X (Print)
IS  - 0026-895X (Linking)
VI  - 70
IP  - 5
DP  - 2006 Nov
TI  - Hypoxia-inducible factor-1 (HIF-1).
PG  - 1469-80
AB  - Adaptation to low oxygen tension (hypoxia) in cells and tissues leads to the 
      transcriptional induction of a series of genes that participate in angiogenesis, 
      iron metabolism, glucose metabolism, and cell proliferation/survival. The primary 
      factor mediating this response is the hypoxia-inducible factor-1 (HIF-1), an 
      oxygen-sensitive transcriptional activator. HIF-1 consists of a constitutively 
      expressed subunit HIF-1beta and an oxygen-regulated subunit HIF-1alpha (or its 
      paralogs HIF-2alpha and HIF-3alpha). The stability and activity of the alpha 
      subunit of HIF are regulated by its post-translational modifications such as 
      hydroxylation, ubiquitination, acetylation, and phosphorylation. In normoxia, 
      hydroxylation of two proline residues and acetylation of a lysine residue at the 
      oxygen-dependent degradation domain (ODDD) of HIF-1alpha trigger its association 
      with pVHL E3 ligase complex, leading to HIF-1alpha degradation via 
      ubiquitin-proteasome pathway. In hypoxia, the HIF-1alpha subunit becomes stable 
      and interacts with coactivators such as cAMP response element-binding protein 
      binding protein/p300 and regulates the expression of target genes. Overexpression 
      of HIF-1 has been found in various cancers, and targeting HIF-1 could represent a 
      novel approach to cancer therapy.
FAU - Ke, Qingdong
AU  - Ke Q
AD  - Nelson Institute of Environmental Medicine, New York University School of 
      Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA.
FAU - Costa, Max
AU  - Costa M
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20060803
PL  - United States
TA  - Mol Pharmacol
JT  - Molecular pharmacology
JID - 0035623
RN  - 0 (Hypoxia-Inducible Factor 1)
SB  - IM
MH  - Animals
MH  - Gene Expression Regulation
MH  - Humans
MH  - Hypoxia-Inducible Factor 1/chemistry/genetics/*metabolism
RF  - 183
EDAT- 2006/08/05 09:00
MHDA- 2006/12/09 09:00
CRDT- 2006/08/05 09:00
PHST- 2006/08/05 09:00 [pubmed]
PHST- 2006/12/09 09:00 [medline]
PHST- 2006/08/05 09:00 [entrez]
AID - mol.106.027029 [pii]
AID - 10.1124/mol.106.027029 [doi]
PST - ppublish
SO  - Mol Pharmacol. 2006 Nov;70(5):1469-80. doi: 10.1124/mol.106.027029. Epub 2006 Aug 
      3.