PMID- 16888040
OWN - NLM
STAT- MEDLINE
DCOM- 20061107
LR  - 20230418
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 103
IP  - 33
DP  - 2006 Aug 15
TI  - Microfluidic vias enable nested bioarrays and autoregulatory devices in Newtonian 
      fluids.
PG  - 12280-4
AB  - We report on a fundamental technological advance for multilayer 
      polydimethylsiloxane (PDMS) microfluidics. Vertical passages (vias), connecting 
      channels located in different layers, are fabricated monolithically, in parallel, 
      by simple and easy means. The resulting 3D connectivity greatly expands the 
      potential complexity of microfluidic architecture. We apply the vias to printing 
      nested bioarrays and building autoregulatory devices. A current source is 
      demonstrated, while a diode and a rectifier are derived; all are building blocks 
      for analog circuitry in Newtonian fluids. We also describe microfluidic septa and 
      their applications. Vias lay the foundation for a new generation of microfluidic 
      devices.
FAU - Kartalov, Emil P
AU  - Kartalov EP
AD  - Department of Biochemistry and Molecular Biology, Keck School of Medicine and 
      Norris Cancer Center, University of Southern California, NOR6346, 1441 Eastlake 
      Avenue, Los Angeles, CA 90033, USA. kartalov@usc.edu
FAU - Walker, Christopher
AU  - Walker C
FAU - Taylor, Clive R
AU  - Taylor CR
FAU - Anderson, W French
AU  - Anderson WF
FAU - Scherer, Axel
AU  - Scherer A
LA  - eng
GR  - R01 HG002644/HG/NHGRI NIH HHS/United States
GR  - 1R01 HG002644-01A1/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20060803
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Dimethylpolysiloxanes)
RN  - 0 (Silicones)
RN  - 63148-62-9 (baysilon)
SB  - IM
MH  - Dimethylpolysiloxanes/*chemistry
MH  - Electrochemistry/instrumentation/methods
MH  - Equipment Design
MH  - Homeostasis
MH  - Microchemistry/instrumentation/methods
MH  - *Microfluidic Analytical Techniques
MH  - *Microfluidics/instrumentation/methods
MH  - Nanotechnology/instrumentation/methods
MH  - Silicones/*chemistry
PMC - PMC1567871
COIS- Conflict of interest statement: No conflicts declared.
EDAT- 2006/08/05 09:00
MHDA- 2006/11/09 09:00
PMCR- 2007/02/03
CRDT- 2006/08/05 09:00
PHST- 2006/08/05 09:00 [pubmed]
PHST- 2006/11/09 09:00 [medline]
PHST- 2006/08/05 09:00 [entrez]
PHST- 2007/02/03 00:00 [pmc-release]
AID - 0602890103 [pii]
AID - 3137 [pii]
AID - 10.1073/pnas.0602890103 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12280-4. doi: 
      10.1073/pnas.0602890103. Epub 2006 Aug 3.