PMID- 16888169
OWN - NLM
STAT- MEDLINE
DCOM- 20060925
LR  - 20060804
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 1070
DP  - 2006 Jul
TI  - Expression and GTP sensitivity of peptide histidine isoleucine 
      high-affinity-binding sites in rat.
PG  - 215-9
AB  - High-affinity-binding sites for the vasoactive intestinal peptide (VIP) analogs 
      peptide histidine/isoleucine-amide (PHI)/carboxyterminal methionine instead of 
      isoleucine (PHM) are expressed in numerous tissues in the body but the nature of 
      their receptors remains to be elucidated. The data presented indicate that PHI 
      discriminated a high-affinity guanosine 5'-triphosphate (GTP)-insensitive-binding 
      subtype that represented the totality of the PHI-binding sites in newborn rat 
      tissues but was differentially expressed in adult animals. The GTP-insensitive 
      PHI/PHM-binding sites were also observed in CHO cells over expressing the VPAC2 
      but not the VPAC1 VIP receptor.
FAU - Debaigt, Colin
AU  - Debaigt C
AD  - IPBC CNRS-UMR 6187 Pole Biologie Sante, 40 avenue du Recteur Pineau, 86022 
      Poitiers Cedex, France.
FAU - Meunier, Annie-Claire
AU  - Meunier AC
FAU - Goursaud, Stephanie
AU  - Goursaud S
FAU - Montoni, Alicia
AU  - Montoni A
FAU - Pineau, Nicolas
AU  - Pineau N
FAU - Couvineau, Alain
AU  - Couvineau A
FAU - Laburthe, Marc
AU  - Laburthe M
FAU - Muller, Jean-Marc
AU  - Muller JM
FAU - Janet, Thierry
AU  - Janet T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (Peptide PHI)
RN  - 0 (Receptors, Vasoactive Intestinal Peptide, Type II)
RN  - 0 (Receptors, Vasoactive Intestinal Polypeptide, Type I)
RN  - 0 (Recombinant Proteins)
RN  - 86-01-1 (Guanosine Triphosphate)
SB  - IM
MH  - Animals
MH  - Binding Sites
MH  - CHO Cells
MH  - Cricetinae
MH  - Guanosine Triphosphate/*pharmacology
MH  - Liver/*drug effects/*metabolism
MH  - Peptide PHI/*metabolism/*pharmacology
MH  - Rats
MH  - Receptors, Vasoactive Intestinal Peptide, Type II/genetics/metabolism
MH  - Receptors, Vasoactive Intestinal Polypeptide, Type I/genetics/metabolism
MH  - Recombinant Proteins/metabolism
MH  - Sensitivity and Specificity
EDAT- 2006/08/05 09:00
MHDA- 2006/09/26 09:00
CRDT- 2006/08/05 09:00
PHST- 2006/08/05 09:00 [pubmed]
PHST- 2006/09/26 09:00 [medline]
PHST- 2006/08/05 09:00 [entrez]
AID - 1070/1/215 [pii]
AID - 10.1196/annals.1317.017 [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2006 Jul;1070:215-9. doi: 10.1196/annals.1317.017.