PMID- 16889106
OWN - NLM
STAT- MEDLINE
DCOM- 20060905
LR  - 20240320
IS  - 1294-8322 (Print)
IS  - 1958-5969 (Electronic)
IS  - 1294-8322 (Linking)
VI  - 8
IP  - 2
DP  - 2006
TI  - Rating scales in depression: limitations and pitfalls.
PG  - 207-15
AB  - Since the introduction of antidepressants to psychopharmacology in the 1960s, the 
      Hamilton Depression Rating Scale (HAM-D) has been the most frequently used rating 
      scale for depression. When used as a scale for prediction of outcome with 
      antidepressants, the HAM-D, by its total score, has obtained limited use 
      analogous to the Diagnostic and Statistical Manual of Mental Disorders. 4th ed 
      (DSM-IV) diagnosis of major depression. Most research has been devoted to the use 
      of the HAM-D to discriminate between placebo and active drugs or to show 
      dose-response relationship in patients with major depression. An improvement in 
      the total HAM-D score during a drug trial does not, however, in itself qualify 
      the drug as an antidepressant, because the total score is not a sufficient 
      statistic. The problem of statistical versus clinical significance when analyzing 
      placebo-controlled trials, including dose-response relationship, is outlined, 
      with the recommendation to use effect size statistics.
FAU - Bech, Per
AU  - Bech P
AD  - Psychiatric Research Unit, Frederiksborg General Hospital, Hillerod, Denmark. 
      pebe@fa.dk
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Dialogues Clin Neurosci
JT  - Dialogues in clinical neuroscience
JID - 101238198
RN  - 0 (Antipsychotic Agents)
SB  - IM
MH  - Antipsychotic Agents/therapeutic use
MH  - Depression/*diagnosis/drug therapy/physiopathology/psychology
MH  - *Diagnostic and Statistical Manual of Mental Disorders
MH  - Humans
MH  - *Personality Inventory
MH  - *Psychiatric Status Rating Scales
PMC - PMC3181766
EDAT- 2006/08/08 09:00
MHDA- 2006/09/06 09:00
PMCR- 2006/06/01
CRDT- 2006/08/08 09:00
PHST- 2006/08/08 09:00 [pubmed]
PHST- 2006/09/06 09:00 [medline]
PHST- 2006/08/08 09:00 [entrez]
PHST- 2006/06/01 00:00 [pmc-release]
AID - 10.31887/DCNS.2006.8.2/pbech [doi]
PST - ppublish
SO  - Dialogues Clin Neurosci. 2006;8(2):207-15. doi: 10.31887/DCNS.2006.8.2/pbech.