PMID- 16890190
OWN - NLM
STAT- MEDLINE
DCOM- 20061010
LR  - 20190402
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 348
IP  - 2
DP  - 2006 Sep 22
TI  - Aberrantly regulated proteins in frontotemporal dementia.
PG  - 465-72
AB  - Non-Alzheimer's disease of the frontal type, or frontotemporal dementia (FTD), is 
      the second most common form of dementia. Yet, a detailed characterization of the 
      disease has been especially limiting. To identify mechanisms possibly involved in 
      disease pathology or progression, a proteomic analysis of proteins isolated from 
      human frontal cortex with frontotemporal dementia and parkinsonism linked to 
      chromosome 17 (FTDP-17) was performed. We used 2D gel electrophoresis and 
      MALDI-TOF to identify a total of 24 proteins differentially expressed in FTDP-17. 
      We identified a ubiquitin C-terminal hydrolase, UCHL1, as well as several 
      proteins involved in oxidative stress to be differentially expressed. Data 
      presented implicate UCHL1 and ubiquitin-mediated degradation as well as oxidative 
      stress response in disease pathology or progression.
FAU - Schweitzer, Kelly
AU  - Schweitzer K
AD  - Department of Pathology and Laboratory Medicine, Indiana University School of 
      Medicine, Indianapolis, IN 46202, USA. kschwei2@jhmi.edu
FAU - Decker, Emily
AU  - Decker E
FAU - Zhu, Liping
AU  - Zhu L
FAU - Miller, Richard E
AU  - Miller RE
FAU - Mirra, Suzanne S
AU  - Mirra SS
FAU - Spina, Salvatore
AU  - Spina S
FAU - Ghetti, Bernardino
AU  - Ghetti B
FAU - Wang, Mu
AU  - Wang M
FAU - Murrell, Jill
AU  - Murrell J
LA  - eng
GR  - P30 AG10133/AG/NIA NIH HHS/United States
GR  - R01 NS37431/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20060728
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (UCHL1 protein, human)
RN  - 0 (Ubiquitin)
RN  - 9007-73-2 (Ferritins)
RN  - EC 3.4.19.12 (Ubiquitin Thiolesterase)
SB  - IM
MH  - Chromosomes, Human, Pair 17/genetics
MH  - Dementia/*physiopathology
MH  - Electrophoresis, Gel, Two-Dimensional
MH  - Female
MH  - Ferritins/metabolism
MH  - Frontal Lobe/chemistry/metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Tissue Proteins/*metabolism
MH  - Oxidative Stress/genetics
MH  - Proteomics
MH  - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
MH  - Ubiquitin/metabolism
MH  - Ubiquitin Thiolesterase/genetics
EDAT- 2006/08/08 09:00
MHDA- 2006/10/13 09:00
CRDT- 2006/08/08 09:00
PHST- 2006/06/29 00:00 [received]
PHST- 2006/07/17 00:00 [accepted]
PHST- 2006/08/08 09:00 [pubmed]
PHST- 2006/10/13 09:00 [medline]
PHST- 2006/08/08 09:00 [entrez]
AID - S0006-291X(06)01623-8 [pii]
AID - 10.1016/j.bbrc.2006.07.113 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2006 Sep 22;348(2):465-72. doi: 
      10.1016/j.bbrc.2006.07.113. Epub 2006 Jul 28.