PMID- 16890297
OWN - NLM
STAT- MEDLINE
DCOM- 20061129
LR  - 20131121
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 179
IP  - 1-2
DP  - 2006 Oct
TI  - Insulin-like growth factor-I enhances the biological activity of brain-derived 
      neurotrophic factor on cerebrocortical neurons.
PG  - 186-90
AB  - Insulin-like growth factor (IGF)-I and brain-derived neurotrophic factor (BDNF) 
      act within the brain to enhance neuronal survival and plasticity. We extend these 
      findings by showing that the presence of both neurotrophins is required to 
      depress the rise in intracellular Ca2+ caused by glutamate in primary cultures of 
      cerebrocortical neurons. IGF-I enhanced expression of BDNF receptors (Trk-B) and 
      increased the ability of BDNF to induce ERK1/2 phosphorylation. This 
      IGF-I-induced increase in BDNF responsiveness describes a new interaction between 
      these peptides in the brain.
FAU - McCusker, Robert H
AU  - McCusker RH
AD  - 250 Edward R Madigan Laboratory, Urbana, IL 61801-3873, USA. rmccuske@uiuc.edu
FAU - McCrea, Katherine
AU  - McCrea K
FAU - Zunich, Samantha
AU  - Zunich S
FAU - Dantzer, Robert
AU  - Dantzer R
FAU - Broussard, Suzanne R
AU  - Broussard SR
FAU - Johnson, Rodney W
AU  - Johnson RW
FAU - Kelley, Keith W
AU  - Kelley KW
LA  - eng
GR  - AG 2004-35206-14144/AG/NIA NIH HHS/United States
GR  - AG023580/AG/NIA NIH HHS/United States
GR  - MH 51569/MH/NIMH NIH HHS/United States
GR  - MH71349/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20060804
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Blotting, Western
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Calcium/metabolism
MH  - Cerebral Cortex/*metabolism
MH  - Extracellular Signal-Regulated MAP Kinases/metabolism
MH  - Glutamic Acid/metabolism
MH  - Insulin-Like Growth Factor I/*metabolism
MH  - Intracellular Fluid/metabolism
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Neurons/*metabolism
MH  - Phosphorylation
MH  - Receptor, trkB/metabolism
EDAT- 2006/08/08 09:00
MHDA- 2006/12/09 09:00
CRDT- 2006/08/08 09:00
PHST- 2006/04/24 00:00 [received]
PHST- 2006/06/14 00:00 [revised]
PHST- 2006/06/14 00:00 [accepted]
PHST- 2006/08/08 09:00 [pubmed]
PHST- 2006/12/09 09:00 [medline]
PHST- 2006/08/08 09:00 [entrez]
AID - S0165-5728(06)00228-1 [pii]
AID - 10.1016/j.jneuroim.2006.06.014 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2006 Oct;179(1-2):186-90. doi: 10.1016/j.jneuroim.2006.06.014. 
      Epub 2006 Aug 4.