PMID- 16890377
OWN - NLM
STAT- MEDLINE
DCOM- 20061012
LR  - 20151119
IS  - 0306-4530 (Print)
IS  - 0306-4530 (Linking)
VI  - 31
IP  - 8
DP  - 2006 Sep
TI  - Brain-derived neurotrophic factor Val66Met polymorphism and dexamethasone/CRH 
      test results in depressed patients.
PG  - 1019-25
AB  - Data suggest that both neurotrophic and hypothalamic-pituitary-adrenocortical 
      (HPA) systems are involved in the pathophysiology of depression. The aim of the 
      present study was to investigate whether the non-conservative brain-derived 
      neurotrophic factor (BDNF) Val66Met polymorphism has an impact on HPA axis 
      activity in depressed patients. At admission, the dexamethasone/CRH (DEX/CRH) 
      test was performed in 187 drug-free in-patients suffering from major depression 
      or depressed state of bipolar disorder (DSM-IV criteria). Moreover, genotyping of 
      BDNF Val66Met polymorphism was carried out using the fluorescence resonance 
      energy transfer method (FRET). Homozygous carriers of the Met/Met genotype showed 
      a significantly higher HPA axis activity during the DEX/CRH test than patients 
      carrying the Val/Val or Val/Met genotype (ACTH, cortisol). Our results further 
      contribute to the hypothesized association between HPA axis dysregulation and 
      reduced neuroplasticity in depression and are consistent with the assumption that 
      BDNF is a stress-responsive intercellular messenger modifying HPA axis activity.
FAU - Schule, Cornelius
AU  - Schule C
AD  - Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University of 
      Munich, Nussbaumstr. 7, 80336 Munich, Germany. 
      Cornelius.Schuele@med.uni-muenchen.de
FAU - Zill, Peter
AU  - Zill P
FAU - Baghai, Thomas C
AU  - Baghai TC
FAU - Eser, Daniela
AU  - Eser D
FAU - Zwanzger, Peter
AU  - Zwanzger P
FAU - Wenig, Nadine
AU  - Wenig N
FAU - Rupprecht, Rainer
AU  - Rupprecht R
FAU - Bondy, Brigitta
AU  - Bondy B
LA  - eng
PT  - Journal Article
PL  - England
TA  - Psychoneuroendocrinology
JT  - Psychoneuroendocrinology
JID - 7612148
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7S5I7G3JQL (Dexamethasone)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adrenocorticotropic Hormone/blood
MH  - Adult
MH  - Amino Acid Substitution
MH  - Bipolar Disorder/psychology
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - *Corticotropin-Releasing Hormone
MH  - Depressive Disorder/*genetics/*psychology
MH  - Depressive Disorder, Major/psychology
MH  - *Dexamethasone
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Hydrocortisone/metabolism
MH  - Hypothalamo-Hypophyseal System/physiology
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Psychiatric Status Rating Scales
EDAT- 2006/08/08 09:00
MHDA- 2006/10/13 09:00
CRDT- 2006/08/08 09:00
PHST- 2006/04/11 00:00 [received]
PHST- 2006/06/14 00:00 [revised]
PHST- 2006/06/20 00:00 [accepted]
PHST- 2006/08/08 09:00 [pubmed]
PHST- 2006/10/13 09:00 [medline]
PHST- 2006/08/08 09:00 [entrez]
AID - S0306-4530(06)00112-0 [pii]
AID - 10.1016/j.psyneuen.2006.06.002 [doi]
PST - ppublish
SO  - Psychoneuroendocrinology. 2006 Sep;31(8):1019-25. doi: 
      10.1016/j.psyneuen.2006.06.002.