PMID- 16890754
OWN - NLM
STAT- MEDLINE
DCOM- 20060908
LR  - 20061115
IS  - 0091-6749 (Print)
IS  - 0091-6749 (Linking)
VI  - 118
IP  - 2
DP  - 2006 Aug
TI  - Recent progress in the biology of airway dendritic cells and implications for 
      understanding the regulation of asthmatic inflammation.
PG  - 331-6
AB  - Dendritic cells (DCs) are crucial in determining the outcome of antigen encounter 
      and integrating signals derived from the antigen, its inflammatory context, and 
      the host environment into a signal that can be read by naive T cells in the 
      lymphoid tissues and by effector T cells in peripheral tissues. Airway DC 
      subsets, however, induce different types of immune responses, with plasmacytoid 
      DCs promoting tolerance and myeloid DCs inducing immunity. We also propose that 
      airway DCs are not only crucial for sensitization to inhaled antigens, leading to 
      allergy, but also play a crucial role in established inflammation and therefore 
      represent a therapeutic target to prevent the development of airway diseases.
FAU - Hammad, Hamida
AU  - Hammad H
AD  - Department of Pulmonary Medicine, Erasmus University Medical Center, Dr 
      Molewaterplein 50, 3015 GE Rotterdam, The Netherlands. H.Hammad@erasmusmc.nl
FAU - Lambrecht, Bart N
AU  - Lambrecht BN
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20060519
PL  - United States
TA  - J Allergy Clin Immunol
JT  - The Journal of allergy and clinical immunology
JID - 1275002
RN  - 0 (Allergens)
SB  - IM
MH  - Allergens/immunology
MH  - Animals
MH  - Asthma/*immunology
MH  - Cell Movement
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Lung/immunology
MH  - Lymph Nodes/immunology
MH  - Pneumonia/*immunology
MH  - T-Lymphocytes, Helper-Inducer/immunology
MH  - T-Lymphocytes, Regulatory/immunology
RF  - 46
EDAT- 2006/08/08 09:00
MHDA- 2006/09/09 09:00
CRDT- 2006/08/08 09:00
PHST- 2006/02/15 00:00 [received]
PHST- 2006/03/28 00:00 [revised]
PHST- 2006/03/30 00:00 [accepted]
PHST- 2006/08/08 09:00 [pubmed]
PHST- 2006/09/09 09:00 [medline]
PHST- 2006/08/08 09:00 [entrez]
AID - S0091-6749(06)00854-2 [pii]
AID - 10.1016/j.jaci.2006.03.041 [doi]
PST - ppublish
SO  - J Allergy Clin Immunol. 2006 Aug;118(2):331-6. doi: 10.1016/j.jaci.2006.03.041. 
      Epub 2006 May 19.