PMID- 16891615
OWN - NLM
STAT- MEDLINE
DCOM- 20060920
LR  - 20061115
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 1071
DP  - 2006 Jul
TI  - Developmental trauma is associated with behavioral hyperarousal, altered HPA axis 
      activity, and decreased hippocampal neurotrophin expression in the adult rat.
PG  - 542-6
AB  - Effects of early-life trauma on adult behavioral responses, corticosterone (CORT) 
      concentration, and levels of nerve growth factor (NGF), brain-derived neutrophic 
      factor (BDNF), and neurotrophin-3 (NT-3) in hippocampus and frontal cortex were 
      investigated. Traumatized animals showed an increase in rearing in both the 
      elevated plus maze and open field after adult restress, higher basal levels of 
      CORT, lower levels of BDNF in dorsal hippocampus, and lower levels of NT-3 in 
      dorsal and ventral hippocampus. Trauma-related behavioral hyperarousal and 
      altered hypothalamic-pituitary-adrenal (HPA) axis activity may be mediated by 
      decreases in hippocampal neurotrophin expression.
FAU - Uys, Joachim D K
AU  - Uys JD
AD  - MRC Unit for Anxiety and Stress Related Disorders, Department of Medical 
      Physiology, University of Stellenbosch, Tygerberg 7505, South Africa. 
      jduys@sun.ac.za
FAU - Marais, Lelanie
AU  - Marais L
FAU - Faure, Jacqueline
AU  - Faure J
FAU - Prevoo, Desiree
AU  - Prevoo D
FAU - Swart, Pieter
AU  - Swart P
FAU - Mohammed, Abdul H
AU  - Mohammed AH
FAU - Stein, Dan J
AU  - Stein DJ
FAU - Daniels, Willie M U
AU  - Daniels WM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Neurotrophin 3)
SB  - IM
MH  - Animals
MH  - Animals, Newborn/*physiology
MH  - Arousal/*physiology
MH  - Behavior, Animal/*physiology
MH  - Brain-Derived Neurotrophic Factor/biosynthesis
MH  - Hippocampus/*metabolism
MH  - Hypothalamo-Hypophyseal System/*physiopathology
MH  - Male
MH  - Nerve Growth Factors/*biosynthesis
MH  - Neurotrophin 3/biosynthesis
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Wounds and Injuries/metabolism/*physiopathology/*psychology
EDAT- 2006/08/08 09:00
MHDA- 2006/09/21 09:00
CRDT- 2006/08/08 09:00
PHST- 2006/08/08 09:00 [pubmed]
PHST- 2006/09/21 09:00 [medline]
PHST- 2006/08/08 09:00 [entrez]
AID - 1071/1/542 [pii]
AID - 10.1196/annals.1364.060 [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2006 Jul;1071:542-6. doi: 10.1196/annals.1364.060.