PMID- 16892324
OWN - NLM
STAT- MEDLINE
DCOM- 20061019
LR  - 20200930
IS  - 1552-4825 (Print)
IS  - 1552-4825 (Linking)
VI  - 140A
IP  - 17
DP  - 2006 Sep 1
TI  - A father of four consecutive trisomic pregnancies with elevated frequencies of 
      associated aneuploid sperm.
PG  - 1840-5
AB  - A couple with normal somatic karyotypes had four consecutive trisomic 
      pregnancies, each involving a different chromosome, of which two children were 
      liveborn with confirmed paternal-origin trisomies. The apparently healthy father 
      produced abnormally high frequencies of disomic sperm for each of the four 
      chromosomes involved in the trisomic pregnancies (P< 0.003, by sperm fluorescence 
      in situ hybridization (FISH)). His elevated sperm aneuploidies persisted over a 
      2-year period and affected all chromosomes evaluated, suggesting that he had a 
      genome-wide defect in meiotic disjunction. He also had the highest frequencies of 
      aneuploid sperm reported for any healthy man to date. His frequencies of 
      aneuploid sperm were comparable to the peak frequencies of the transient 
      responses reported in some cancer patients after receiving aneugenic 
      chemotherapies. These findings indicate that apparently healthy men can produce 
      abnormally high frequencies of sperm aneuploidies that suggest that this 
      condition may contribute to recurrent trisomic pregnancies.
FAU - Tomascik-Cheeseman, Lisa M
AU  - Tomascik-Cheeseman LM
AD  - Biosciences Directorate, Lawrence Livermore National Laboratory (LLNL), 
      Livermore, California, USA.
FAU - Lowe, Xiu R
AU  - Lowe XR
FAU - Eskenazi, Brenda
AU  - Eskenazi B
FAU - Kidd, Sharon
AU  - Kidd S
FAU - Nath, Joginder
AU  - Nath J
FAU - Moore, Dan 2nd
AU  - Moore D 2nd
FAU - Wyrobek, Andrew J
AU  - Wyrobek AJ
LA  - eng
GR  - P42ES04705/ES/NIEHS NIH HHS/United States
GR  - R01 ES09117-02/ES/NIEHS NIH HHS/United States
GR  - Y01-ES-10203-00/ES/NIEHS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Am J Med Genet A
JT  - American journal of medical genetics. Part A
JID - 101235741
SB  - IM
MH  - Adult
MH  - *Aneuploidy
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Pedigree
MH  - Pregnancy
MH  - Spermatozoa/cytology/metabolism/*ultrastructure
MH  - *Trisomy
EDAT- 2006/08/08 09:00
MHDA- 2006/10/20 09:00
CRDT- 2006/08/08 09:00
PHST- 2006/08/08 09:00 [pubmed]
PHST- 2006/10/20 09:00 [medline]
PHST- 2006/08/08 09:00 [entrez]
AID - 10.1002/ajmg.a.31391 [doi]
PST - ppublish
SO  - Am J Med Genet A. 2006 Sep 1;140A(17):1840-5. doi: 10.1002/ajmg.a.31391.