PMID- 16892552
OWN - NLM
STAT- MEDLINE
DCOM- 20060912
LR  - 20061115
IS  - 0070-4113 (Print)
IS  - 0070-4113 (Linking)
VI  - 88
DP  - 2004
TI  - [Multiprobe FISH for enhanced prediction of recurrent bladder cancer].
PG  - 194-8
AB  - The early detection of recurrent urothelial cancer is a great challenge for both 
      urologists and pathologists. Cytology is a sensitive and highly specific tool for 
      the diagnosis of high-grade bladder cancer and carcinoma in situ, but is not 
      reliable in low-grade tumors. Therefore, cystoscopy has remained the gold 
      standard for surveillance after resection of bladder cancer. Recent data suggest 
      that multi-target fluorescence in situ hybridization (FISH) can markedly improve 
      the sensitivity of urinary cytology. The goal of this study was to investigate 
      the utility of the recently developed FISH assay Uro-Vysion for the prediction of 
      recurrence during surveillance. 134 bladder washes obtained during a negative 
      follow-up cystoscopy from 127 patients were analyzed. Positive cytology was 
      strongly associated with subsequent recurrence, emphasizing the importance of 
      conventional cytology for bladder cancer surveillance. A positive UroVysion FISH 
      test significantly predicted recurrence when cases with rare tetraploic cells 
      were considered as negative. Taken together, both cytology and FISH help to 
      better determine the risk of bladder cancer recurrence in order to establish more 
      individualized follow-up schemes.
FAU - Zellweger, T
AU  - Zellweger T
AD  - Urologische Universitatsklinik BS/BL, Liestal, Schweiz.
FAU - Benz, G
AU  - Benz G
FAU - Herzog, M
AU  - Herzog M
FAU - Grilli, B
AU  - Grilli B
FAU - Mihatsch, M J
AU  - Mihatsch MJ
FAU - Gasser, T C
AU  - Gasser TC
FAU - Bubendorf, L
AU  - Bubendorf L
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - FISH fur eine verbesserte Abschatzung des rezidivrisikos nach transurethraler 
      Resektion von Urothelkarzinomen.
PL  - Germany
TA  - Verh Dtsch Ges Pathol
JT  - Verhandlungen der Deutschen Gesellschaft fur Pathologie
JID - 7503704
SB  - IM
MH  - Cystoscopy
MH  - Follow-Up Studies
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Recurrence
MH  - Survival Analysis
MH  - Urinary Bladder Neoplasms/mortality/*pathology/surgery
MH  - Urothelium/pathology
EDAT- 2006/08/09 09:00
MHDA- 2006/09/13 09:00
CRDT- 2006/08/09 09:00
PHST- 2006/08/09 09:00 [pubmed]
PHST- 2006/09/13 09:00 [medline]
PHST- 2006/08/09 09:00 [entrez]
PST - ppublish
SO  - Verh Dtsch Ges Pathol. 2004;88:194-8.